Are there any special considerations when treating a patient with anal cancer who has poorly managed HIV/AIDS?

In the early days of AIDS, prior to the development of HAART, standard chemoradiation ("Nigro") was very poorly tolerated, and it was necessary to omit or dose-reudce the mitomycin, and many patients could not tolerate the full dose of radiation, stopping treatment early because of toxicity. Outcome...

While there are some conflicting data, I think the evidence points to treating patients who have well controlled HIV the same as their HIV-negative counterparts. Multiple reports suggest no difference in oncologic outcomes or toxicity based on presence of HIV infection and management with HAART (PMI...