General Internal Medicine

Dementia

Questions discussed in this category

How do you manage sleep disturbances in patients with Alzheimer’s disease without relying heavily on deliriogenic medications?

2 Answers available

How do stroke-risk considerations affect your use of atypical antipsychotics for patients with dementia?

Related Q&A on antipsychotics in Alzheimer's.In light of the publication from Choma et al., PMID 41063545.

2 Answers available

Are there scenarios in which you would advise using benzodiazepines for the treatment of hyperactive delirium?

1 Answer available

How do you choose among SSRIs and dosing strategies for the management of behavioral and psychological symptoms of dementia?

What factors might drive decisions for different SSRIs and/or doses?

1 Answer available

Would you recommend a GLP-1 agonist as an option to reduce the risk of dementia in patients with a strong family history?

Seminer et al., PMID 40193122

1 Answer available

What is your antipsychotic of choice and general titration regimen in the outpatient setting for a patient with dementia and behavioral disturbances (assuming reversible causes such as urinary retention, constipation, etc. have been addressed)?

2 Answers available

How do you approach balancing the treatment of urinary incontinence with anticholinergic medications with the use of cholinesterase inhibitors in dementia?

1 Answer available

Papers discussed in this category

The American journal of psychiatry, 2016-05-01

Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial.

The American journal of psychiatry, 2016-05-01

Effects of Citalopram on Neuropsychiatric Symptoms in Alzheimer's Dementia: Evidence From the CitAD Study.

JAMA, 2014 Feb 19

Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial.

Frontiers in aging neuroscience, 2023 Mar 03

Comparative efficacy and safety of antidepressant therapy for the agitation of dementia: A systematic review and network meta-analysis.

Journal of Alzheimer's disease : JAD, 2020

The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).

Journal of the American Geriatrics Society, 2025 Apr 28

Treatment of Inappropriate Sexual Behavior in Persons With Dementia: A Systematic Review.

JAMA, 2011-09-28

Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

The Cochrane database of systematic reviews, 2014-03-21

Pharmacotherapies for sleep disturbances in Alzheimer's disease.

Translational psychiatry, 2022 Apr 01

Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings.

Journal of sleep research, 2020 Dec 02

Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2016 Jan 27

Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022 Dec 01

Effects of quetiapine on sleep: A systematic review and meta-analysis of clinical trials.

CNS drugs, 2024 Aug 09

Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis.

General Internal Medicine

Dementia

Questions discussed in this category

Papers discussed in this category

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