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General Internal Medicine

Dementia   

Questions discussed in this category

What is your antipsychotic of choice and general titration regimen in the outpatient setting for a patient with dementia and behavioral disturbances (assuming reversible causes such as urinary retention, constipation, etc. have been addressed)?
3 Answers available
In older adults with mild cognitive impairment, do you ever prescribe cholinesterase inhibitors and/or memantine?
How do you counsel patients on this off-label use?
7 Answers available
How do you differentiate cognitive impairment from normal age-related cognitive decline?
Especially in the era of novel AD biomarkers (blood-based, CSF, PET scans), AD treatments, and new definitions of Alzheimer's (Alz Association 2025) -...
2 Answers available
How do you select between antipsychotics in the treatment of delirium refractory to nonpharmacological management in hospitalized older adults with dementia?
From a geriatrics harm-reduction standpoint, can we recommend any particulars regarding dosing or selection of therapies when used as a last resort?
2 Answers available
How do you approach the management of older adult patients with dementia who repeatedly aspirate with oral intake but whose family/HCP may be unwilling to accept the aspiration risk associated with comfort eating?
Considering poor outcomes/lack of long-term benefit for NGT/PEG placement in this population.
2 Answers available
What are your thoughts about lion's mane supplementation to slow the decline or improve cognitive capacity for those at risk of dementia?
1 Answer available
How do you manage sleep disturbances in patients with Alzheimer’s disease without relying heavily on deliriogenic medications?
2 Answers available
How do stroke-risk considerations affect your use of atypical antipsychotics for patients with dementia?
Related Q&A on antipsychotics in Alzheimer's.In light of the publication from Choma et al., PMID 41063545.
2 Answers available
Are there scenarios in which you would advise using benzodiazepines for the treatment of hyperactive delirium?
1 Answer available
How do you choose among SSRIs and dosing strategies for the management of behavioral and psychological symptoms of dementia?
What factors might drive decisions for different SSRIs and/or doses?
1 Answer available
Would you recommend a GLP-1 agonist as an option to reduce the risk of dementia in patients with a strong family history?
As studied in Tang H, Donahoo WT, DeKosky ST, et al. GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related De...
1 Answer available
How do you approach balancing the treatment of urinary incontinence with anticholinergic medications with the use of cholinesterase inhibitors in dementia?
1 Answer available


Papers discussed in this category

The American journal of psychiatry, 2016-05-01
Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial.
The American journal of psychiatry, 2016-05-01
Effects of Citalopram on Neuropsychiatric Symptoms in Alzheimer's Dementia: Evidence From the CitAD Study.
JAMA, 2014 Feb 19
Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial.
Frontiers in aging neuroscience, 2023 Mar 03
Comparative efficacy and safety of antidepressant therapy for the agitation of dementia: A systematic review and network meta-analysis.
Journal of Alzheimer's disease : JAD, 2020
The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).
Journal of the American Geriatrics Society, 2025 Apr 28
Treatment of Inappropriate Sexual Behavior in Persons With Dementia: A Systematic Review.
Journal of the American Geriatrics Society, 2016 Mar 23
Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis.
The Cochrane database of systematic reviews, 2018 Jun 18
Antipsychotics for treatment of delirium in hospitalised non-ICU patients.
JAMA, 2011-09-28
Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.
Psychiatry research, 2020 Dec 13
The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia.
The Cochrane database of systematic reviews, 2014-03-21
Pharmacotherapies for sleep disturbances in Alzheimer's disease.
Translational psychiatry, 2022 Apr 01
Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings.
Journal of sleep research, 2020 Dec 02
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2016 Jan 27
Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022 Dec 01
Effects of quetiapine on sleep: A systematic review and meta-analysis of clinical trials.
CNS drugs, 2024 Aug 09
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis.
Journal of oncology practice, 2017-10
REMAP: A Framework for Goals of Care Conversations.
Journal of the American Geriatrics Society, 2019 Aug 20
Swallowing Disorders in the Older Population.
Handbook of clinical neurology, 2022
Prognostication in dementia.
Journal of the American Geriatrics Society, 2014 Jul 17
American Geriatrics Society feeding tubes in advanced dementia position statement.
JAMA, 2025 Aug 12
Eating and Swallowing Problems in People With Advanced Dementia.

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