Medical Oncology

ctDNA

Questions discussed in this category

Why does NCCN still not recommend using circulating tumor DNA to guide adjuvant chemotherapy in stage II colon cancer when colon cancer experts are currently embracing the practice?

4 Answers available

How, if at all, are you employing ctDNA in the management of patients with colon cancer?

3 Answers available

For patients with resected colon cancer, to what extent would you adapt adjuvant chemotherapy if ctDNA results don't correspond with your initial treatment recommendation?

6 Answers available

How do you approach early-stage breast cancer patients who are asking for ctDNA or tumor marker surveillance (or previously receiving these with another provider) when these are not part of the NCCN or ASCO guidelines?

2 Answers available

How would positive ctDNA results after 12 cycles of adjuvant FOLFOX affect your management for patients with colon cancer?

4 Answers available

Papers discussed in this category

N Engl J Med, 2022 Jun 04

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.

JCO precision oncology, 2022 Jul

Reply to F. Dayyani et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 May 15

Oxaliplatin in Adjuvant Colorectal Cancer: Is There a Role in Older Patients?

JAMA network open, 2024 Dec 02

Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection.

JAMA network open, 2022 Mar 01

Evaluation of Comparative Surveillance Strategies of Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen Levels in Patients With Resected Colorectal Cancer.

Nat Med, 2023 Jan 16

Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer.

Nature medicine, 2025 Mar 07

Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial.

International journal of molecular sciences, 2025 Mar 11

Circulating Tumor DNA as a Real-Time Biomarker for Minimal Residual Disease and Recurrence Prediction in Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis.

JAMA surgery, 2024 Jan 01

Applications of Liquid Biopsy for Surgical Patients With Cancer: A Review.

Journal of the National Comprehensive Cancer Network : JNCCN, 2024 Dec

ctDNA/MRD Testing for Colon Cancer: A Work in Progress or Ready for Prime-Time Standard of Care?

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