Medical Oncology

General Rheumatology

Questions discussed in this category

What is your approach to working up diarrhea in an immunocompromised patient?

How do you approach immunosuppression in patients with a positive Interferon Gamma Release Assay and prior intravesicular BCG treatment for bladder cancer?

Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?

1 Answer available

How do you manage a patient with cervical cancer who has FDG uptake in bilateral ischial tuberosities with lytic areas on CT correlate, and also has a history suspicious for untreated polymyalgia rheumatica with chronic symptoms in the same anatomic locations?

Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP.

4 Answers available

Is there a concern for the potential of future congenital malformations in offspring when preservation of eggs and sperm is done AFTER cyclophosphamide treatment given that it is an alkylating agent?

1 Answer available

How do you approach evaluation and management of arthralgia in a patient after CAR-T cell therapy?

1 Answer available

What would be the main indications for opting for biosimilars over an original biologic, outside of insurance barriers?

Are there any instances where you would prefer a biosimilar rather than the reference product?

2 Answers available

How do you approach the workup for a patient with persistently elevated inflammatory markers (CRP and ESR) whose history and exam do not point to a clear cause?

4 Answers available

How do you interpret elevations in ESR and CRP in the setting of increased BMI?

4 Answers available

What is the appropriate management of arthralgias associated with bosutinib?

1 Answer available

Would you consider continuing a biologic for difficult to control autoimmune disease in a patient with a recent diagnosis of a surgically curable solid malignancy?

Would you favor the use of any particular biologics over others?

1 Answer available

How do you manage psoriatic arthritis in patients who are planning to start treatment with checkpoint inhibitors for underlying malignancy?

2 Answers available

Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

1 Answer available

When a patient with a preexisting rheumatic disease and on immunotherapy begins to flare, how do you decide if this is an underlying rheumatic disease activity versus an immunotherapy related adverse event?

How do you decide if it may be safe to continue immunotherapy?

1 Answer available

How are you timing the third dose of the COVID-19 mRNA vaccine in patients on rituximab?

1 Answer available

Do you recommend shingles vaccine to all immunosuppressed patients under the age of 50 y.o.?

1 Answer available

How do you handle hypogammaglobulinemia detected in patients prior to maintenance rituximab infusion?

2 Answers available

Papers discussed in this category

JAMA network open, 2018-11-02

Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.

J Rheumatol, 2019 Apr 01

Therapy with Biologic Agents After Diagnosis of Solid Malignancies: Results from the Corrona Registry.

RMD Open,

How do we use biologics in rheumatoid arthritis patients with a history of malignancy? An assessment of treatment patterns using Scandinavian registers.

Annals of internal medicine, 2018-01-16

Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease: A Systematic Review.

J Immunother Cancer,

Combination anti-PD1 and ipilimumab therapy in patients with advanced melanoma and pre-existing autoimmune disorders.

Arthritis & rheumatology (Hoboken, N.J.), 2018-03

The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.

PET Clin, 2020 Feb 11

18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis.

Rheumatology (Oxford), 2022 Jul 22

PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.

Arthritis Care Res (Hoboken), 2017 Dec

Impact of Obesity and Adiposity on Inflammatory Markers in Patients With Rheumatoid Arthritis.

JAMA, 1999 Dec 08

Elevated C-reactive protein levels in overweight and obese adults.

Reumatologia, 2020 Feb 28

The impact of obesity on inflammatory markers used in the assessment of disease activity in rheumatoid arthritis - a cross-sectional study.

Rheumatology (Sunnyvale, Calif.), 2015 May 07

Polymyalgia Rheumatica and its Association with Cancer.

Annals of the rheumatic diseases, 2013 Jul 10

Is cancer associated with polymyalgia rheumatica? A cohort study in the General Practice Research Database.

Medical Oncology

General Rheumatology

Questions discussed in this category

Papers discussed in this category

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