Pediatric Hematology/Oncology

Cancer Predisposition

Questions discussed in this category

How would you approach breast cancer screening in an adolescent patient with a CDH1 mutation?

1 Answer available

Would you use a matched sibling donor with a germline heterozygous BRCA1 mutation for stem cell transplant?

Presuming there are no matched unrelated donors.

1 Answer available

What adjustments, if any, do you make to chemotherapy regimens for patients with chromosomal breakage disorders who develop malignancy?

Are there particular drugs you avoid or dose-adjustments that are recommended?

1 Answer available

How would you treat a young patient with classical intermediate-risk Hodgkin lymphoma who has an underlying DNA repair-deficiency disorder, such as congenital mismatch repair disorder or ataxia telangiectasia?

How does your treatment approach vary depending on the underlying predisposition?

1 Answer available

Papers discussed in this category

Cancers (Basel), 2022 Apr 14

Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders.

Hered Cancer Clin Pract, 2021 Apr 01

Should the BCRA1/2-mutations healthy carriers be valid candidates for hematopoietic stem cell donation?

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