Gastrointestinal Cancers   

How reliable is somatic testing to detect an underlying germline predisposition?

Would you have reservations in treating patients with breast, GI, or pelvic malignancies with radiation alone or concurrent chemoradiation?

What are there most evidence-based options?

Are you placing more weight on patient risk factors such as age >65 or co-morbidities?

How do you prevent early menopause in women? Please comment on freezing of eggs, oophopexy, supine vs prone position, vaginal dialator.