Pediatric Hematology/Oncology

CML

Questions discussed in this category

Would you change therapy for a CML patient in hematologic remission on imatinib found with positive qualitative BCR-ABL1 for the p230 protein?

qPCR for BCR/ABL was negative. FISH remained positive.

1 Answer available

Do you recommend continued PCR testing in a CML patient who underwent allogeneic stem cell transplantation with an identical match about 20 years ago?

1 Answer available

Do you switch from imatinib to another TKI in patients with chronic phase CML who develop renal insufficiency?

There are conflicting reports whether it contributes to renal insufficiency. If you do switch, what is your preferred TKI in this scenario?

2 Answers available

Should a teenager diagnosed with CML in blast crisis go to transplant once MRD is negative?

2 Answers available

Papers discussed in this category

Biol Blood Marrow Transplant, 2019 Jul 01

Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party.

Ann Hematol, 2015 Mar 27

Management of chronic myeloid leukemia in blast crisis.

Leukemia, 2008-12

Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase.

J Clin Pharmacol, 2021 Jul 16

Pharmacokinetics of Asciminib in Individuals With Hepatic or Renal Impairment.

Leukemia, 2023 Sep 19

Survival with chronic myeloid leukaemia after failing milestones.

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