Pediatric Hematology/Oncology

General Hepatology

Questions discussed in this category

Can defibrotide be given safely for VOD in patients with refractory thrombocytopenia to platelet transfusions?

In a patient with recurrent fibrolamellar HCC a year after upfront resection (previously refused adjuvant therapy) with a solitary abdominal mass, would you offer neoadjuvant therapy to assess response?

Or offer resection followed by adjuvant therapy?

2 Answers available

How do you approach relapsed hepatocellular malignant neoplasm NOS after transplant in pediatric or AYA patients?

2 Answers available

What would be your next line of treatment for disease control in a pediatric patient with metastatic hepatocellular carcinoma in partial response after multiple therapies?

The patient already received PLADO+sorafenib, Y90, and Atezolizumab/Bevacizumab complicated by recurrent episodes of bleeding from esophageal varices....

2 Answers available

How do you approach treatment of metastatic hepatocellular carcinoma in an adolescent?

Would you offer liver transplant in the setting of metastatic disease?

1 Answer available

Papers discussed in this category

Blood, 2016-03-31

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.

Bone marrow transplantation, 2016-07

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

Bone marrow transplantation, 2018-02

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.

British journal of haematology, 2020 Mar 04

Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation.

Blood advances, 2022 Jan 11

Defibrotide: real-world management of veno-occlusive disease/sinusoidal obstructive syndrome after stem cell transplant.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2020 Jan-Dec

A Meta-Analysis Evaluating the Incidence of Bleeding Events With Intravenous Defibrotide Treatment Outside the Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome Setting.

Bone marrow transplantation, 2022 Dec 23

Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study.

Pediatric Hematology/Oncology

General Hepatology

Questions discussed in this category

Papers discussed in this category

Related Topics in Pediatric Hematology/Oncology