Pediatric Oncology

Osteosarcoma

Questions discussed in this category

Should high-dose methotrexate be used in the treatment of AYA patients with osteosarcoma?

Is there utility in administering adjuvant chemotherapy to a patient with relapsed osteosarcoma for whom CR2 is achieved after surgical resection alone?

1 Answer available

How would you treat osteosarcoma that has relapsed with unresectable pulmonary metastatic disease?

4 Answers available

When should upfront molecular sequencing be performed in a pediatric or AYA patient with sarcoma?

1 Answer available

How do you manage patients with a history of severe ifosfamide neurotoxicity who need additional ifosfamide?

What is the role of methylene blue prophylaxis?

1 Answer available

Is there utility in metronomic chemotherapy in adolescent and young adult patients with refractory sarcoma?

2 Answers available

Is there a maximum ifosfamide cumulative dose in patients with normal kidney function?

When offering ifosfamide / etoposide for relapsed osteosarcoma, patient is being given 2.8mg/m2 of ifosfamide. Is 6-8 cycles exceeding any known lifet...

1 Answer available

Would you recommend bone scan or PET-CT for detecting metastatic bony lesions in a patient with osteosarcoma?

Do you find that one method is more sensitive than the other?

1 Answer available

Papers discussed in this category

Cancer, 2017-06-15

Treatment pathway of bone sarcoma in children, adolescents, and young adults.

Cancer chemotherapy and pharmacology, 1994

Renal function in children and adolescents following 72 g/m2 of ifosfamide.

Journal of pediatric hematology/oncology, 1997

A feasibility, toxicity, and early response study of etoposide, ifosfamide, and vincristine for the treatment of children with rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS) IV pilot study.

Medical and pediatric oncology, 1999-02

Renal function following combination chemotherapy with ifosfamide and cisplatin in patients with osteogenic sarcoma.

Am J Pediatr Hematol Oncol,

Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor.

Pediatric blood & cancer, 2014-04

A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer.

Cancer medicine, 2019-01

Safety and efficacy of high-dose methotrexate for osteosarcoma in adolescents compared with young adults.

Journal of the National Cancer Institute, 1988-07-06

The role of methotrexate in osteosarcoma.

Annals of oncology : official journal of the European Society for Medical Oncology, 2015-02

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.

Anticancer Drugs,

Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.

J Adolesc Young Adult Oncol, 2019 Nov 08

Methotrexate-Etoposide-Ifosfamide Compared with Doxorubicin-Cisplatin-Ifosfamide Chemotherapy in Osteosarcoma Treatment, Patients Aged 18-25 Years.

Pediatric Oncology

Osteosarcoma

Questions discussed in this category

Papers discussed in this category

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