Radiation Oncology

Renal Cell Carcinoma

Questions discussed in this category

How do you dose or sequence therapy to overcome radioresistance from oligometastatic disease from RCC?

Do you typically recommend SBRT? What dose? Or do you ever recommend surgery or surgery followed by XRT?

1 Answer available

How would you approach adjuvant systemic therapy for an isolated, oligometastatic CNS recurrence of RCC that was treated with SBRT?

3 Answers available

If the patient has had prior partial nephrectomy for RCC, would you consider SBRT for a contralateral RCC?

Assume the patient is not a candidate for surgery. What dose would you use? Would you recommend a lower dose to not damage the patient's kidney functi...

1 Answer available

Would you offer SBRT to a biopsy proven T1 renal cell carcinoma on a transplanted kidney?

1 Answer available

In metastatic/recurrent clear cell carcinoma with a solitary site of metastasis to the bone when, if ever, do you consider local therapy adequate and hold systemic therapy?

1 Answer available

What are your top takeaways from ASCO GU 2022?

6 Answers available

What dose/fractionation scheme would you use for a bulky (>15 cm) metastatic renal cell carcinoma deposit with brachial plexus encasement and spinal canal invasion?

No cord compression is present, and the patient remains symptomatic only with their upper extremity due to brachial plexopathy

2 Answers available

How would you treat oligometastatic kidney cancer in a young, fit patient with recurrence <6 months after nephrectomy?

Is the short time to recurrence a reason to not consider definitive management with surgery/radiation? Should systemic therapy be added if pursuing d...

1 Answer available

Do you offer postoperative radiation for adrenocortical carcinoma?

If so, how would you design and deliver the treatment?

1 Answer available

In light of the recently published CARMENA trial, is there still a role for cytoreductive nephrectomy in metastatic RCC patients?

1 Answer available

How would you treat a patient with widely metastatic clear cell RCC who has undergone craniotomy/resection of a single brain metastasis?

In the setting of recent craniotomy and a plan for SRS to the surgical cavity, which systemic therapy would you choose and when would you start it?

2 Answers available

Papers discussed in this category

International journal of radiation oncology, biology, physics, 2015-06-01

Adjuvant radiation therapy improves local control after surgical resection in patients with localized adrenocortical carcinoma.

American journal of clinical oncology, 1991-04

Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.

Surgery, 2012-12

Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more often after laparoscopic adrenalectomy than after open adrenalectomy.

Annals of surgical oncology, 2018-07

Adjuvant Radiation is Associated with Improved Survival for Select Patients with Non-metastatic Adrenocortical Carcinoma.

Cancer,

Radiotherapy in adrenocortical carcinoma.

J Clin Endocrinol Metab, 2006 Aug 08

Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma.

J Cancer Res Ther,

Adjuvant radiotherapy after surgical resection for adrenocortical carcinoma: A systematic review of observational studies and meta-analysis.

J Clin Endocrinol Metab,

Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma.

N. Engl. J. Med., 2018 Jun 03

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma.

European urology focus, 2019-11

The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis.

Int J Radiat Oncol Biol Phys, 2021 Mar 29

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Preclinical Models Enhances Single-Agent Immune Checkpoint Blockade.

N Engl J Med,

Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.

Frontiers in surgery, 2022 Jul 29

Role of metastasectomy in the management of renal cell carcinoma.

European urology open science, 2022 Jan 18

Circulating Tumor DNA in Patients with Renal Cell Carcinoma. A Systematic Review of the Literature.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2019-01

Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data.

JAMA oncology, 2021 Dec 01

Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma.

CA: a cancer journal for clinicians, 2022 Jun 16

An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma.

JAMA oncology, 2019-06-01

Single-Fraction Stereotactic vs Conventional Multifraction Radiotherapy for Pain Relief in Patients With Predominantly Nonspine Bone Metastases: A Randomized Phase 2 Trial.

International journal of radiation oncology, biology, physics, 2021 Jan 08

Phase 3 Multi-Center, Prospective, Randomized Trial Comparing Single-Dose 24 Gy Radiation Therapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer.

European urology, 2021 Dec 23

Stereotactic Radiotherapy and Short-course Pembrolizumab for Oligometastatic Renal Cell Carcinoma-The RAPPORT Trial.

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