Infectious Disease
Expert guidance on antimicrobial stewardship, emerging infections, and complex infectious disease management.
Recent Discussions
Are you using the microbial cell-free DNA “Karius” test to aid in the diagnosis of an atypical pulmonary infection such as PJP or NTM?
No, not at this time. Intriguing, but not sure we know enough yet.
Do you consider use of convalescent plasma early in disease course in COVID-19 induced ARDS in mechanically ventilated patients?
At this time, I have not adopted the use of convalescence plasma in COVID-19-induced ARDS. I have read the Belgian study but I believe more evidence from other similar studies is needed before we accept it as standard of care. I have not seen any COVID-19-induced ARDS for almost 18 months.
How do you approach patients with onychomycosis that does not respond to terbinafine and prolonged courses of fluconazole?
Terbinafine is usually effective in the treatment of the most common nail infections. Failure of treatment with terbinafine and fluconazole should make us consider bacterial co-infection or other non-dermatophyte organisms (i.e., aspergillus or non-C albicans). Fungal cultures are often falsely nega...
What is your approach to use of D-mannose for prevention of recurrent uncomplicated cystitis?
Unfortunately, in light of Hayward et al., PMID 38587819, I think there is a very limited role for the use of D-mannose for the prevention of recurrent uncomplicated cystitis. Our evidence-based options for the prevention of recurrent uncomplicated cystitis in postmenopausal women without catheters ...
Does management of NMDA receptor encephalitis change in a patient with HIV/AIDS?
In a patient who is immunodeficient, one must be mindful of the risk of opportunistic infections from additional immunosuppression. With that being said, I would still proceed with first-line therapy (pulse steroids and oral taper, IVIG) and symptomatic/supportive care with anti-seizure medicines an...
Do you treat HIV/AIDS-associated CNS vasculitis with antiretrovirals alone or in combination with steroids?
This is a tough question and like most viral associated forms of vasculitis i.e., HCV, VZ, other... of unclear immunopathogenic mechanisms, it is approached empirically. Antiviral therapy is the cornerstone but at least short-term immunosuppression is generally needed in the acute phase as host medi...
How do you counsel HIV patients with an undetectable viral load on breastfeeding?
People who are virally suppressed on ART are at very low risk of transmission to infants through breastfeeding, less than 1%-- however, the rate is not 0, and any infant with HIV is heartbreaking. The risks are particularly high in infants who are transitioning to solid foods (potentially related to...
Do you periodically check a urine culture for patients without dysuria but who have a history of struvite kidney stones and urinary tract infections with urease producing organisms?
Struvite nephrolithiasis is caused by a high urine pH (usually>7.0). Typically, a urine this alkaline requires urinary infection with a bacterium that produces urease, (Proteus, Providencia, Klebsiella) which in turn splits naturally occurring urea into ammonium, driving the pH to supraphysiologic l...
For AML patients, when do you stop antiinfective agents?
Our practice is typically to continue an anti-viral throughout induction/consolidation without stopping the agent. We typically utilize anti-bacterial and anti-fungal when the absolute neutrophil count (ANC) is under 500 and then stop them once the ANC recovers to above 500. Our preferred anti-funga...
What duration of therapy do you use for treatment of Legionella pneumonia in an immunocompetent host without associated empyema or extrapulmonary infection?
We have little experience of legionellosis, especially in immunocompetent patients. Based on the available information and the published recommendations (these follow), I would generally treat patients for 5-7 days, depending on clinical response.A recent review: Viasus et al., PMID 35505000IDSA/ATS...