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Infectious Disease
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How do you approach a well controlled HIV patient with diffuse cutaneous kaposi sarcoma who failed to respond to radiation, paclitaxel and monthly liposomal doxorubicin?
1 Answers
Mednet Member
Medical Oncology · University Hospitals
Please consider using Pomalidomide 5 mg PO daily (21 days on and seven days off in a 28-day cycle). (Polizotto et al., PMID 27863194). There is significant activity in HIV-positive patients of this regimen (ORR-60%). The NCCN also endorses Pomalyst as a treatment for KS. Other than this, checkpoint ...
Do you treat patients with HIV-AIDS and positive cryptococcal antigenemia but negative CSF cryptococcal antigen with standard meningitis treatment given the potential for the postzone effect?
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1 AnswersMednet Member
Infectious Disease · VA Connecticut Healthcare System
Hello, What was his CD4 and HIV VL results? What were the LP results exactly: what were the cell count, protein, and glucose levels? Did he have symptoms consistent with meningitis, and what did the head CT show? These patients can sometimes have cryptococcal pneumonia and not meningitis, by the way...