Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
How do you incorporate TTFields into your clinical practice?
I recommend TTFields to all patients with newly diagnosed glioblastoma. I generally approach this during the second or third week of radiation treatment. I present TTFields as part of standard treatment for glioblastoma, similar to the discussion of adjuvant temozolomide.
How would you manage locoregionally advanced NSCLC with extensive tracheal "mucosal malignant" skip lesions covering almost the entire trachea?
Although I've never encountered this exact situation in practice, I would say that this is very similar to cases that require extensive mediastinal radiation to cover all of their gross nodal disease. My prescription would remain 60Gy in 30 fractions and I would attempt to meet the standard esophage...
Do you hold pelvic radiation for patient with clostridium difficile-associated diarrhea?
No. I proceed with radiation unless the diarrhea is not treatable with fluids and treat the C difficile with antibiotics. I am not aware of any data showing worsened toxicity of radiation concurrent with C difficile infection.
Do you routinely prescribe PCP prophylaxis for patients who will be on steroids long-term?
Yes. This is something I don't think is emphasized enough given the ease of the intervention and seriousness of infection. In my first year of practice, I saw 3 fatal cases of PCP in patients that were receiving steroids from medical oncology without PCP prophylaxis. So I prescribe it for virtually ...
Is there any data to support SLNB instead of ALND in patients with clinically N2-3 breast cancer after neoadjuvant chemotherapy?
The sentina trial and acsog trial had Predominant N1 disease and negative predictive value Of SNLN is not known for N2 or N3 disease
Would you recommend scrotal RT in a patient with stage IV primary testicular lymphoma with CNS involvement after CR to RCHOP and MTX?
Irradiation to the contralateral testis is an important component of any successful curative regimen for patients with all stages of disease.In a survey by IELSG (JCO 2003), patients who did not receive contralateral testicular RT had a 43% incidence of testicular failure after CR to anthracycline b...
How do you evaluate PSA decline after EBRT for low-and intermediate risk prostate cancer not treated with ADT?
This is not an answer that comes with any hard data, although both NCCN and AUA offer guidelines on PSA monitoring after therapy. First, I check a PSA at treatment completion. This is not so important when ADT is used, as PSA pretty much universally will decline (at least initially) on ADT. However,...
Would you offer adjuvant radiation to a patient with uterine undifferentiated sarcoma s/p resection, vaginal cuff recurrence, and re-resection?
Following principles of managing sarcoma, I would favor RT with a combination of EBRT and brachy.
Is there evidence for dose escalation of large bony metastases secondary to hepatocellular carcinoma?
Interesting question. The thing with HCC bone mets is that if you use only a nuclear bone scan to contour GTV you miss tumor, according to a paper from Korea (1), because HHC bone mets tend to have large soft tissue components. Further, a Japan report(2) from 1998, looked at successful pain relief o...
Would you recommend chemoradiation to the pelvis for a patient with squamous cell carcinoma of the anus metastatic to the liver who has had a complete response to chemotherapy in the pelvis and a liver resection?
The patient is very fortunate. Oligometastases in anal cancer is not a well-studied phenomenon. I do think that this patient is at risk of recurrence in the pelvis, which could be very symptomatic. For this reason, I would suggest radiation therapy. And probably at doses used in the early days of tr...