Questions discussed in this category

I.e. platelet count <30. Would your management change if HIT were only suspected rather than confirmed?  

Provided that the platelet count is normal, do you usually consider this to be a potential erroneous result or do you pursue additional workup for RBC...

Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.

How often do you monitor ADAMTS-13 levels off therapy?

For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?

Does having a concurrent consumptive process e.g. DIC change your management? 

Would you consider high-dose dexamethasone (deliberating adverse effects of antenatal steroids) or move to next-line therapies?

At what point would you recommend transfusion? At what point would you stop radiation?

Papers discussed in this category

Blood, 2021 Apr 01

Blood, 2015 May 13

Blood, 2009 Nov 06


J Pharm Pract, 2019 Mar 27

Journal of vascular and interventional radiology : JVIR, 2012 Apr 17

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2013-10

Journal of clinical medicine, 2023 Nov 03

Blood, 2018 Sep 10

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013-01

Seminars in dialysis, 2014

Kidney Int, 2012 May 16

European journal of haematology, 2003-08

Blood, 2016 Apr 25

Autoimmunity reviews, 2018 Apr 07