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Do you offer palliative whole liver radiation for patients with diffuse liver metastases?

What dose-fractionation scheme do you utilize? Are there particular groups of patients this would not be a good option for (i.e. histologies of disease, Child-Pugh score)?
3 Answers
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Radiation Oncology · Mayo Clinic, Rochester
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Whole liver radiation is a very good palliative treatment for diffuse hepatic metastases causing pain or severe nausea/vomiting. I treat the whole liver plus a 1 cm margin to 7-8 Gy/1 fraction per the Phase II trial from Princess Margaret Hospital (Soliman et al., PMID 24062394). In this trial of 41...

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Radiation Oncology · Brigham and Women's Hospital
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I have also found palliative whole liver (or nearly whole liver) radiation to provide effective palliation for patients with a very extensive liver disease burden and pain due to distension of the liver capsule. I have generally used this only in patients who no longer have any systemic therapy opti...

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Radiation Oncology · The University of Hong Kong
Answered on

Great discussion on whole liver RT. I am wondering if anybody ever used 20-30 Gy in 10 fractions whole liver RT we did 3 decades ago.

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