Do you recommend progesterone for endometrial protection in a young woman on estrogen replacement therapy for iatrogenic menopause after definitive radiation therapy for locally advanced cervical cancer?
If so, what do you typically prescribe?
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What hormone replacement therapy do you recommend for women who have undergone definitive chemoradiation for locally advanced cervical cancer prior to menopause?
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2 Answers
Mednet MemberInvited Expert
Gynecologic Oncology · Cooper Medical School of Rowan University
Answered on
For women with a uterus, I give a combination of estrogen and progesterone therapy, even after definitive radiation therapy. Transdermal preparations have the advantage of bypassing first-pass effect of the liver, but oral combinations are also acceptable.
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Mednet MemberInvited Expert
Radiation Oncology · Abramson Cancer Center, University of Pennsylvania
Answered on
Our group published a relevant review on this topic
A potential algorithm a clinic can use is reproduced here
Fig. 1. Practical approach to initial diagnosis and management of radiation-induced premature ovarian insufficiency (POI) in a radiation oncology practice.
*Menopaus...
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