Do you still recommend protons for grade 2 and grade 3 glioma, following the Soprano study results showing a survival detriment?

I should start by saying that I generally do not recommend proton therapy for grade 2-3 gliomas in adults unless there is a clear and specific indication. Modern photon techniques such as VMAT are highly conformal, efficient, and safe, and they form the backbone of the evidence base that guides our ...

Proton therapy is generally considered less deleterious (harmful) than traditional photon radiation for brain tumors. In this non-randomized study from the Netherlands and Belgium, 373 consecutive patients (256 with WHO grade 2 IDHm gliomas and 117 with WHO grade 3 IDH gliomas) were treated postoper...

The APPROACH study in the UK, which is a randomised study for grade 2 and 3 oligodendroglioma looking at neurocognitive effects with PBT vs X-rays, has temporarily closed accrual to the grade 3 arm of the trial following publication of this abstract.

However, as outlined above by Dr. @Dr. First Last,...