Topics:
Radiation Oncology • Thoracic Malignancies
Does an EGFR mutation in a never-smoker change your radiation treatment recommendations for ES-SCLC?
Do you recommend that standard 30/10 TRT approach or a more aggressive non-small cell like approach (e.g. CRT of locally advanced thoracic disease or SBRT for limited thoracic disease)? Would this clinical picture make you target oligomets with SBRT?
Answer from: Radiation Oncologist at Academic Institution
First, worth a close pathology review at a specialty center. EGFR mutations in de novo small cell are exquisitely rare. The more common scenario is small cell transformation from adenocarcinoma. If this has features of adenocarcinoma, I’d favor a metastatic non small cell paradigm with EGFR in...
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