Does the use of slow release hormone replacement therapy impact your adjuvant treatment recommendations for a perimenopausal patient with an intermediate Oncotype score?
For example, if a patient had testosterone pellets injected, perhaps making endocrine therapy less efficacious, would that sway you to use chemo?
Answer from: Medical Oncologist at Academic Institution
If she had a testosterone pellet this would not sway me to give chemo in someone who would otherwise get endocrine therapy alone. I would give the AI and monitor estradiol levels as the pellet wears off. Small studies of testosterone + anastrozole pellets didn't detect increased estradiol levels whe...
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