MD Anderson   

Questions discussed in this category



If CCRT is pursued, would you move forward with durvalumab consolidation? Assume the patient with ECOG PS 0 and no co-morbidities. How might this chan...

Do you feel differently about using these in patients with a history of HR-negative breast cancer?

Patient previously received neoadjuvant ddAC-T with residual disease at surgery, followed by adjuvant capecitabine which was completed 2 months prior ...

Would you choose to incorporate HER2-targeting agents, chemotherapy, endocrine therapy, or a mix of these?

Do features such as nodal involvement, Ki-67, degree of ER positivity, etc. change your management? Would you use any gene expression assays to help y...

How would you approach additional systemic therapy? Would the clinical stage of the cancer affect your management?

Patient had a clinical T2N0 cancer at diagnosis, completed 6 cycles TCHP, and had 0.2mm residual disease with 80% cellularity, negative sentinel node.

For example, if a patient had testosterone pellets injected, perhaps making endocrine therapy less efficacious, would that sway you to use chemo?

Do your recommendations differ if patients are pre or postmenopausal given the data?

I.e. either for treatment of high-risk disease or intolerance/contraindication to tamoxifen. Will you continue it for the full 5 year course?

In a patient with isolated leptomeningeal disease (no systemic disease), would you still recommend systemic therapy?

Do you reserve this approach for only women with triple negative breast cancer or all-comers?

At what point do you send these test, and in what instances do the results influence your treatment recommendations?


Papers discussed in this category


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JAMA, 2018-02-20

JAMA Oncol,

The New England journal of medicine, 2014-07-10

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Fertility and sterility, 2016-03

Breast Cancer, 2017-09-01

Lancet (London, England), 2013-03-09

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-04-20

Journal of the National Cancer Institute, 2013-07-17

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-09-01

The New England journal of medicine, 2016-07-21

The Lancet. Oncology, 2019-01

Cancer investigation, 2011-11

Clinical cancer research : an official journal of the American Association for Cancer Research, 2009-12-01

Cancer Treat. Rev., 2011-10-01

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Nat Rev Clin Oncol, 2016-08-01

The New England journal of medicine, 2018-07-12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

The New England journal of medicine, 2019-02-14

The New England journal of medicine, 2018-07-12

Lancet Oncol., 2018 Nov 06

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-08-20

J Clin Oncol, 2020 Apr 28

Blood, 2009-09-03

The New England journal of medicine, 2016-08-25

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-08-10

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Cancer medicine, 2019-01

Journal of the National Cancer Institute, 1988-07-06

Annals of oncology : official journal of the European Society for Medical Oncology, 2015-02

Anticancer Drugs,

J Adolesc Young Adult Oncol, 2019 Nov 08

J Clin Oncol, 2020 Sep 16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-12-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-07-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-07-10

N Engl J Med, 2015 Jan 8

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Bone Marrow Transplant, 2018 Nov 01

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J Clin Oncol,

Cancer Manag Res, 2012 Jun 13

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JAMA, 2011-02-09

Br J Cancer, 2021 Feb 03

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Medicine (Baltimore),

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-08-20

World J Gastroenterol,

Annals of Oncology, 2021 Sep 29

Front Oncol, 2021 Apr 29

Chest, 2020 Aug 14

Chest, 2020 Jul

ERJ Open Res, 2020 Oct

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BMC Cancer, 2019 Aug 19

N Engl J Med, 2022 Apr 11

Annals of oncology : official journal of the European Society for Medical Oncology, 2019-08-01

J Thorac Oncol, 2023 Feb 23

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International journal of cancer, 2019 Feb 19

The Lancet. Respiratory medicine, 2023 May 05

JAMA oncology, 2024 Jan 01