For patients with cT1-T3 cN0 cM0 mid/low rectal cancer seeking organ preservation, what treatment approach do you recommend?

This is an important question; however, the answer is unknown. The key outcome that should be the focal point for the best treatment option, is which treatment strategy results in the most optimal patient reported quality of life and bowel function. Currently, this remains void of prospective, rando...

For patients with cT1-T3a cN0 cM0 mid/low rectal cancer seeking organ preservation, the following treatment approaches may be considered:

Neoadjuvant chemoradiotherapy (CRT) followed by local excision: Phase II trials have documented low rates of local recurrence with CRT followed by transanal excisi...