For patients with triple negative breast cancer who are planned to receive adjuvant pembrolizumab, would you recommend pembrolizumab be held until radiation is complete?

Topics: Breast Cancer • Radiation Oncology • Medical Oncology

For patients who were not neoadjuvantly on pembrolizumab, is it safe to initiate it concurrently with radiation?

Answer from: Radiation Oncologist at Community Practice

This will become a practical issue for radiation oncologists as four drugs are now approved for adjuvant treatment after neoadjuvant chemotherapy including pembro, xeloda, T-DM1, and olaparib. Out of these, olaparib and xeloda were done sequential after radiation as concern about increased side effe...

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Radiation Oncologist at Naval Medical Center San Diego
Do you have concerns about pneumonitis in patients...

Radiation Oncologist at Varian Medical Systems/Allegheny health network
We also, anecdotally, saw a few cases and reported...

Answer from: Radiation Oncologist at Academic Institution

In this article in press, (Bellon et al., PMID 34990776) toxicities were compared in patients receiving concurrent TDM1 versus TH with similar rates of pneumonitis (1.0 vs 0.9%). Small numbers but additional data to support concurrent TDM1, which is what we are standardly doing at our institution.&n...

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