I routinely offer hysterectomy at the time of risk reducing BSO for BRCA1 mutations. There is an approximate ~3% risk of serous uterine cancers in these patients (Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations). Additionally, in patients wh...

I discussed the advantages and disadvantages of hysterectomy as part of risk reducing surgery. There is evidence that patients with BRCA1 mutations are at slightly higher risk of papillary serous endometrial cancer.  Hysterectomy simplifies post-operative hormone replacement therapy.  Fo...