How do you interpret a high positive RNP in the setting of a negative ANA and negative sm/RNP?

Topics: Rheumatology • Systemic lupus erythematosus • General Rheumatology

To my understanding, sm/RNP should also be positive in this situation (and one would assume a positive ANA as well)

Answer from: at Academic Institution

This is a challenging scenario that we often see in clinical practice with our current multiplex assays. A great reference is the following ACR abstract: Clinical Significance of RNP Antibodies in Diagnosis of Systemic Autoimmune Rheumatic Disease When Detected By Multiplex Immunoassay. As demonstr...

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at Harvard Medical School
Thanks for the helpful answer! I would just add th...

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