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Systemic lupus erythematosus   

Questions discussed in this category

How do you approach interpreting a low titer dsDNA (such as crithidia 1:40 to 1:80) in the setting of a moderately elevated ANA without other specific features of SLE?
For example, the patient may have other findings such as an elevated CRP. Would you diagnose SLE, or would you want to see other serologies or finding...
2 Answers available
How do you gain access to quinacrine, and what has your recent experience been?
How long has it been back on the market? What is the typical cost for patients? Are certain compounding pharmacies regularly carrying it? 
4 Answers available
How would you approach the work up of SLE in a patient over 80 years old?
How would you work up an elderly female with persistent anemia secondary to warm AIHA requiring almost monthly transfusion, with positive ANA,dsDNA (b...
3 Answers available
What is your approach to nephrology referral for patients with lupus nephritis?
Do you refer all patients with suspected LN, patients with confirmed LN, or patients with specific features (not responding to usual therapy, certain ...
3 Answers available
What is your approach to practical monitoring of lupus disease activity in clinical practice?
What disease activity index do you find more useful and most practical in a busy clinical setting? How often do you assess it?This question is part of...
1 Answer available
What is your approach to dosing and duration of rituximab for refractory lupus nephritis not responsive to cyclophosphamide or mycophenolate?
Do you add low-dose mycophenolate to use in combination with Rituximab in these patients?
1 Answer available
Do you feel comfortable combining mycophenolate mofetil with azathioprine in patients with lupus?
3 Answers available
Do you choose rituximab or calcineurin inhibitors for patients with class IV/V lupus nephritis who are refractory to standard of care therapies?
1 Answer available
What is your approach to transitioning an SLE patient from a pregnancy incompatible regimen to pregnancy compatible regimen?
For example, when switching from MMF to azathioprine, do you overlap the treatments as you lower the dose of one and add the other?
3 Answers available
How would you manage a case of subcutaneous panniculitis-like T cell lymphoma (A/B) who is already on steroids and methotrexate for autoimmune disease?
1 Answer available
Would you use belimumab in a breastfeeding patient with SLE who has persistent joint pain, leukopenia and elevated dsDNA despite HCQ and azathioprine?
3 Answers available
What is your approach to diagnosis and evaluation of nonbacterial thrombotic endocarditis (Libman-Sacks)?
Patient with negative blood cultures, completed 6 weeks of IV antibiotics and vegetation persists. CT imaging without evidence of malignancy. No evide...
3 Answers available
Any concern for lupus flare in patients undergoing laser hair removal?
2 Answers available
Would you treat a patient aggressively for lupus nephritis if they have persistent proteinuria over 1 gram but cannot get a timely kidney biopsy?
3 Answers available
How would you manage a patient with SLE that has a remote history of positive anti-phospholipid antibodies with a current DVT and now completely negative APLs?
Would you still plan for lifelong anticoagulation in this scenario? 
1 Answer available
Would you increase the hydroxychloroquine dose to more than 5 mg/kg/day in a compliant patient with active non-organ threatening lupus (skin+joints) if serum hydroxychloroquine is not at goal until you reach an acceptable concentration?
3 Answers available
What is your approach to patients with SLE who develop a rash after hydroxychloroquine initiation?
3 Answers available
How do you approach follow up of young patients with isolated +ANA, but no current clinical signs or symptoms of SLE?
This question is part of a collaboration with RheumMadness and is specifically in reference to: Antibodies Before SLE.
7 Answers available
Would you consider the use of rilonacept to treat refractory pericarditis in lupus?
5 Answers available
Do you use anti-DFS70 Ab to help reduce the posttest probability of ANA-positive patients having a systemic autoimmune disease if other autoantibodies are negative?
ANA patients referred to rule out CTD is a work-intensive, costly referral type. If they are positive for Anti-Dense Fine Speckled Protein 70 kDa (DFS...
1 Answer available
How do you approach a negative ANA and positive dsDNA in patients with arthralgia, hair loss, or other UCTD features?
5 Answers available
Would you add voclosporin to mycophenolate for refractory proteinuria in a patient with low EF?
Low EF in the range of 30%
1 Answer available
What would be the clinical role of SGLT-2 inhibitors for lupus nephritis given it has an indication for proteinuria related to CKD?
5 Answers available
Is there a role for voclosporin in non-renal lupus?
1 Answer available
When would you consider a kidney biopsy in a patient with longstanding diabetes and hypertension (baseline creatinine 4-5, 4+ proteinuria) who was recently found to have dsDNA positivity?
1 Answer available
How do you manage patients with SLE undergoing assisted reproductive therapy with estrogenic effects?
2 Answers available
At what point would you consider anticoagulation in a pregnant patient with lupus nephritis and non-nephrotic range proteinuria?
3 Answers available
Do you continue belimumab throughout pregnancy?
4 Answers available
Is it safe to use quinacrine in SLE patients with a history of hydroxychloroquine-associated retinopathy?
3 Answers available
How do you manage recurrent urticarial lesions in a patient with underlying connective tissue disease that is otherwise well-controlled?
3 Answers available
What is your approach to severe discoid lupus refractory to conventional topical and systemic therapies?
(Refractory to mycophenolate, azathioprine, and methotrexate. UpToDate suggests thalidomide or IVIG with mixed efficacy, while there are some case rep...
5 Answers available
What is your approach to using medications that can cause bone marrow suppression in SLE patients who have persistent leukopenia?
3 Answers available
How would you approach immunomodulatory treatment for systemic lupus associated protein losing enteropathy (PLE) in a patient whose clinical course has been complicated by significant infection?
Additionally, is it correct to assume that IV therapies might be preferred vs oral treatment given alterations in GI absorption in PLE? 
1 Answer available
Have you seen drug induced SCLE from IL-17 inhibitors?
And if so, what is your approach to the diagnosis?
1 Answer available
How will you utilize newly FDA approved anifrolumab for SLE in your practice?
2 Answers available
Would you consider utilizing a TNF-inhibitor in a patient with RA/SLE overlap who has already tried methotrexate, hydroxychloroquine, and abatacept?
Female patient in her 20's with RA/SLE has been on steroids and methotrexate, currently on HCQ and Orencia. Failing Orencia with active disease. Want ...
4 Answers available
How do you approach “clearing” a patient with SLE and ESRD for renal transplant?
A specific example would be a clinically quiescent but serologically active patient.
1 Answer available
How do you approach management of patients with lupus and transverse myelitis not responding to pulse dose steroids?
2 Answers available
Would you stop belimumab in a patient with SLE starting ravulizumab (C5 inhibitor) for myasthenia gravis due to concern for additive immunosuppression?
3 Answers available
Are there concerns with using sulfasalazine in SLE?
Extrapolating from reactions with other sulfa medications potentially causes flares.
1 Answer available
How do you monitor patients with cutaneous lupus for progression to SLE?
Do you do blood work? Or do you rely on review of systems?
1 Answer available
Is there practical utility from obtaining CSF autoantibodies in patients with suspected neuropsychiatric systemic lupus erythematosus?
1 Answer available
What is your approach to monitoring a patient with SLE who has persistent hypocomplementemia on hydroxychloroquine, but clinically has resolution of cutaneous symptoms and no other internal organ manifestations of disease?
(C3 just below normal, C4 undetectable)
2 Answers available
What is your workup for CSF studies when evaluating for possible CNS Lupus?
In addition, what formula do you use to calculate the IgG index?
2 Answers available
How do you approach treating patients with lupus profundus?
Do you typically start the patient on hydroxychloroquine?  What work-up do you perform?
1 Answer available
What is your approach to pharmacologic treatment options in a patient with both SLE and Crohn's disease?
A female in her 50s with iatrogenic Cushing's Syndrome presenting for management of SLE with low disease activity (but not remission) in the setting o...
1 Answer available
Would you escalate treatment for a clinically stable/asymptomatic lupus patient with persistent leukopenia/neutropenia, already on hydroxychloroquine?
6 Answers available
What would be your approach to a SLE patient who is triple APS positive, has no prior VTE/obstetric events, is stable on HCQ and low dose aspirin, and wants to become pregnant?
2 Answers available
When prescribing hydroxychloroquine, how do you explain the mechanism of action and how this translates into clinical benefit for the patient?
There are studies that show hydroxychloroquine inhibits autophagy (the orderly degradation and recycling of the contents of the cytoplasm for the cell...
3 Answers available
How would you approach a patient who has well controlled SLE on HCQ but develops cotton wool spots on routine ophthalmologic screening?
4 Answers available
What is your approach to assessing whether oral/nasal ulcerations are features of systemic lupus erythematosus versus from another etiology?
Classically, lupus mouth ulcers are large non-painful blisters at the roof of the mouth. What do you do with small scattered blisters, painful or not ...
1 Answer available
What is your approach to further work-up and management of neutropenia in patients with SLE/RA overlap?
For example, a patient with a bone marrow biopsy that shows normocellular bone marrow. Prior management with leflunomide and HCQ with neutropenia attr...
2 Answers available
Would you use TNF inhibitors in patients with features of SLE, but active peripheral and axial spondylarthritis?
Patient with sacroiliitis on imaging, failure of two NSAIDs.
2 Answers available
What is your approach to discordant dsDNA testing, such as positivity to dsDNA by crithidia but negativity to dsDNA by other modalities?
I get a lot of low false positive ds dna (sometimes high- 300) in quest and labcorp but their crithidia specific dsDNA  labs when repeated are ne...
1 Answer available
Do you ever consider discontinuing hydroxychloroquine in patients with SLE in longstanding remission except in cases of overt toxicity?
This question is part of a collaboration with RheumMadness and is specifically in reference to: Hydroxychloroquine Withdrawal.
2 Answers available
How would you interpret a positive dsDNA in a patient with a negative ANA performed via indirect immunofluorescence?
4 Answers available
What is your approach to checking IgG levels post vaccination to detect common variable immunodeficiency in patients with systemic lupus?
If a deficiency is present, do you consider IVIG to treat non-infectious symptoms such as skin rash, arthritis or hematological abnormalities? 
1 Answer available
Is there a role for hydroxychloroquine for secondary prevention in patients with APS without SLE?
1 Answer available
How do you manage recurrent inflammatory pleural effusions in lupus pleuritis?
1 Answer available
Is there a role for measuring serum mycophenolate mofetil levels (or its active metabolite) in the management of lupus nephritis?
1 Answer available
Do you measure drug levels (particularly hydroxychloroquine or mycophenolate) in your lupus patients?
Several speakers at ACR 2021 commented on the important role of drug levels in the management of these patients and cautioned against adding medicatio...
1 Answer available
Are there any major differences in clinical manifestations or autoantibody profiles in children with SLE based on ethnicity?
2 Answers available
Would you consider using DOACs in a young patient with SLE and Libman-Sacks endocarditis, who is negative for APS?
2 Answers available
Do you routinely monitor the QTc when adding voclosporin to hydroxychloroquine in a patient with lupus nephritis?
1 Answer available
Would you consider use of belimumab in a patient with SLE with recurrent anterior uveitis who failed other treatment options?
Patient failed topical ocular therapies, methotrexate, azathioprine.
2 Answers available
What do you use for treatment induction in pure class V lupus nephritis with nephrotic-range proteinuria when MMF is contraindicated?
2 Answers available
In which clinical scenarios is relying on the urine protein-to-creatinine ratio as a measure of proteinuria unreliable, and interpretations should be made looking at urine protein and urine creatinine separately?
1 Answer available
What are some explanations for the persistent renal outcome disparity gaps affecting certain minority groups of patients with pediatric SLE despite improvement in overall renal outcomes?
What would you suggest to help address these disparities in our own practices?
2 Answers available
How can ethnic representation in clinical research studies in childhood and adult SLE be improved?
This question is part of a collaboration with RheumMadness and is specifically in reference to: EMBRACE
2 Answers available
What are the reasons for SLE specific labs to turn negative?
Patients frequently mention diagnosis of SLE years ago but recent Sm, dsDNA (crithidia) and complements can be normal. Can treatment with medications ...
5 Answers available
How do you approach recurrent costochondritis in an SLE patient with nephritis who is otherwise controlled on MMF and HCQ but can't take NSAIDs?
2 Answers available
How would you approach the treatment of a patient who, during a hospitalization, was initially diagnosed with TTP and treated with PLEX with good response, but renal biopsy then resulted class IV LN along with changes of thrombotic microangiopathy?
4 Answers available
What is your treatment approach to persistent chillblains lesions in the absence of systemic lupus?
1 Answer available
What is your approach to the diagnosis and management of lupus cystitis?
2 Answers available
Are whole blood hydroxychloroquine blood levels helpful in patients taking chloroquine?
And if so, are the target levels similar?
2 Answers available
Do you routinely check G6PD level prior to initiation of hydroxychloroquine?
6 Answers available
How would you treat a patient with active lupus nephritis (class 3/4) who requires PD-1 immunotherapy for refractory metastatic renal cell carcinoma?
2 Answers available
In patients with lupus nephritis on maintenance therapy, is there additional benefit in utilizing 2 grams vs 3 grams of mycophenolate mofetil (MMF) daily?
3 Answers available
Is there a role for low dose aspirin in a patient with AVN in four large joints who has underlying well-controlled SLE and positive APLs but no history of clots?
1 Answer available
How do you approach the continued use of TNF inhibitors in a patient with inflammatory arthritis who develops a positive dsDNA without clinical evidence of drug-induced lupus?
2 Answers available
How would you approach initiating belimumab in a patient with serologic evidence of prior hepatitis B infection?
Such as patients with negative Hepatitis B surface antigen and negative viral load but with positive hepatitis b core antibody.
1 Answer available
What is your approach to ongoing assessment and medication tapering in well controlled discoid lupus without systemic features?
3 Answers available
How long would you consider the use of low-dose aspirin in a patient with SLE and high risk aPL profile (without a clinical event)?
1 Answer available
How do you approach the treatment of bullous cutaneous lupus?
When would you de-escalate therapy?
1 Answer available
What is your approach to management of ongoing scleritis in SLE despite mycophenolate?
1 Answer available
What is your approach to using NIH activity and chronicity indices from renal biopsy in tailoring immunosuppression to a patient with new lupus nephritis?
3 Answers available
Would you consider adding voclosporin to belimumab and MMF in the setting of active proteinuria, rather than switching agents?
3 Answers available
In your experience, is there an association between interstitial cystitis and systemic lupus erythematosus?
2 Answers available
What workup and initial treatment should be considered for suspected autoimmune myelofibrosis?
1 Answer available
Would you consider PLEX for patients with DAH from SLE-associated capillaritis?
1 Answer available
What have you found effective for the chronic fatigue that is often seen in patients with SLE or Sjogren's despite overall good disease control?
1 Answer available
Would you consider anifrolumab in the management of hematologic manifestations in SLE?
2 Answers available
Would you target the same hydroxychloroquine blood level for discoid lupus compared to systemic lupus?
1 Answer available
Do you escalate treatment for reactive lymphadenopathy in an otherwise stable and asymptomatic patient with lupus?
(assuming that the malignancy evaluation has been completed and the lymphadenopathy is confirmed to be reactive)
1 Answer available
How do you use hydroxychloroquine in patients with lupus nephritis on hemodialysis or peritoneal dialysis?
2 Answers available
Would you have any hesitation to use belimumab in a patient with IgA deficiency?
1 Answer available
Do you have any hesitations for combining belimumab with any of the DMARDs in patients with SLE/RA overlap?
2 Answers available
How do you differentiate a lupus flare versus drug-induced lupus in patients with SLE on a drug associated with DILE?
2 Answers available
Do you find IgA isotypes of anti-beta2-glycoprotein antibodies and anticardiolipin antibodies to be clinically useful in the evaluation for APS?
Do you routinely check IgA anticardiolipin and beta-2 glycoprotein antibody IgA in your practice? And how would a positive result change your manageme...
2 Answers available
How do you treat lupus-associated small fiber neuropathy?
1 Answer available
What do you view as reasonable alternatives to cyclophosphamide in the treatment of neuropsychiatric lupus?
4 Answers available
Do you ever consider treatment outside of the peripartum period in a patient with a history of obstetric APS?
i.e. obstretric APS without thrombosis or SLE
2 Answers available
How do you approach the management of immunosuppression in patients with lupus nephritis that go on to dialysis?
3 Answers available
What is your approach to treating severe manifestations of neuropsychiatric SLE in the setting of concomitant infection?
1 Answer available
Is there a role for immunosuppression in patients with triple positive antiphospholipid antibodies who do not meet the clinical criteria for APS?
2 Answers available
What particular pre-operative considerations should we consider for SLE patients undergoing elective surgery?
1 Answer available
How do you approach DMARD therapy in a patient with lupus and recurrent pericarditis?
1 Answer available
How do you approach the use of commercial testing such as AVISE CTD in clinical practice?
1 Answer available
How do you approach immunosuppressive therapy in lupus-associated pulmonary arterial hypertension?
2 Answers available
Would you use voclosporin or belimumab as adjunctive therapy for treatment of lupus nephritis?
Especially given the recent FDA approval of voclosporin, how should we think about the use of this medication for LN? 
3 Answers available
How do you clinically distinguish between cutaneous lupus with photosensitivity and polymorphic light eruption-like reactions?
1 Answer available
Is it ever reasonable to switch to a different TNFi as opposed to switching to an agent in a different class in a case of TNFi induced lupus or psoriasis?
In other words, do we think of TNFi induced lupus and TNFi induced psoriasis as a drug effect or a class effect? 
1 Answer available
What is your approach to differentiating SLE flare in pregnancy vs pre-eclampsia?
1 Answer available
What is your approach to monitoring lipids in patients with rheumatic diseases such as RA and SLE and do you have a lower threshold to start lipid lowering agents compared to the general population?
2 Answers available
Does the presence of ANCA antibodies in patients with newly diagnosed lupus nephritis alter your approach to management?
1 Answer available
How would you approach localized lymphadenopathy in a patient with lupus whose symptoms are otherwise well-controlled?
2 Answers available
How do you approach monitoring of patients found to have a positive anti-dsDNA antibody without other clinical evidence of SLE?
1 Answer available
How would you advise patients with known stable autoimmune thrombocytopenia regarding the Ad26.COV2.S (Johnson & Johnson/Janssen) vaccine?
1 Answer available
How do you approach the use of low-dose aspirin for primary prevention in non-pregnant patients with SLE and positive aPL antibodies, without clinical criteria for APS?
Do you follow the 2019 EULAR Guidelines that SLE patients with asymptomatic, positive aPL should be on low-dose ASA?
1 Answer available
How useful are anti-ribosomal P antibodies in the evaluation for SLE psychosis?
1 Answer available
When is it necessary to monitor the QTc interval in patients on hydroxychloroquine?
2 Answers available
Is it okay to use medications associated with drug-induced lupus in patients with SLE?
1 Answer available
Is there a role for G-CSF treatment for SLE patients with persistent neutropenia?
1 Answer available
What is your approach to treatment of lupus peritonitis?
1 Answer available
Is there a role for measuring hydroxychloroquine blood levels in clinical practice?
If so, are there specific patient populations for which you would use this metric?
1 Answer available
What is your threshold for pursuing bone marrow biopsy in a lupus patient with cytopenias?
2 Answers available
Are you recommending the mRNA COVID-19 vaccines to your patients with immune mediated inflammatory diseases?
5 Answers available
What is your approach to treating refractory thrombocytopenia in lupus?
2 Answers available
Which immunosuppressed patients with SLE would benefit from antibiotic prophylaxis to prevent pneumocystis pneumonia?
1 Answer available
Is it ever appropriate to use hydroxychloroquine temporarily in higher doses (more than 5mg/kg) to control lupus activity such as skin manifestations?
1 Answer available
How do you interpret a high positive RNP in the setting of a negative ANA and negative sm/RNP?
To my understanding, sm/RNP should also be positive in this situation (and one would assume a positive ANA as well)
1 Answer available
How would you attempt to determine the etiology of intracranial hemorrhage in a patient with newly diagnosed lupus and an active viral infection?
1 Answer available
What is your first choice contraceptive agent for women with SLE?
How do you counsel these patients about hormonal agents? 
1 Answer available
Is it okay to use belimumab to treat SLE in a patient who has a history of lymphoma and is on a Bruton's tyrosine kinase inhibitor (such as ibrutinib)?
1 Answer available
Do you think there is a role for belimumab in treating lupus nephritis and if so, in which patients would you considering adding it on?
Did the recently published BLISS-LN trial change your practice?
2 Answers available
Does serologic activity (e.g., high titer dsDNA, low complements) without clinical disease activity in a pregnant lupus patient affect maternal or fetal outcomes?
2 Answers available
Do you continue hydroxychloroquine in lupus patients who develop cardiomyopathy?
1 Answer available
Should gonadotropin-releasing hormone (GnRH) agonists be offered to all women of reproductive age about to undergo treatment with cyclophosphamide?
2 Answers available
What is your approach to bladder cancer surveillance in patients who have received cyclophosphamide?
1 Answer available
How do steroids and/or DMARDs affect biopsy results if a renal biopsy for suspected lupus nephritis is delayed?
1 Answer available
Are there any clinical situations in which checking for anti-chromatin antibodies is helpful?
1 Answer available
How do you counsel patients who ask if there are any dietary modifications they can make to help control their autoimmune disease?
This question is part of a collaboration with RheumMadness and is specifically in reference to: ADIRA Diet
1 Answer available
Is there a minimum work-up necessary in patients with an ANA greater than 1:160 and no clinical symptoms suggestive of lupus (i.e., specific antibodies, UA)?
2 Answers available
Do you use hydroxychloroquine for prevention of neonatal lupus in patients with a positive SSA who are planning on becoming pregnant?
1 Answer available
In the treatment of lupus nephritis, which patients may benefit from the use of rituximab or other B-cell depleting agents during induction?
1 Answer available


Papers discussed in this category

Arthritis and rheumatism, 2012-04
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study.
Ann Rheum Dis, 2013 Jun 05
Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.
Arthritis and rheumatism, 2005-09
Use of a gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus.
Arthritis & rheumatology (Hoboken, N.J.), 2015-05
Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus.
Lupus,
Preservation of fertility and ovarian function and minimizing gonadotoxicity in young women with systemic lupus erythematosus treated by chemotherapy.
Best Pract Res Clin Obstet Gynaecol, 2019 Nov 13
Ovarian protection with gonadotropin-releasing hormone agonists during cyclophosphamide therapy in systemic lupus erythematosus.
J. Am. Coll. Cardiol.,
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.
Arthritis and rheumatism, 1982-11
The 1982 revised criteria for the classification of systemic lupus erythematosus.
Arthritis and rheumatism, 2012-08
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.
, 2019 Aug 06
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus.
Arthritis Rheum.,
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
Arthritis and rheumatism, 2010-01
Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: a data-driven review.
J. Rheumatol., 2019 Sep 01
Malignancies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis: A Population-based Cohort Study.
N Engl J Med,
Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.
Southern medical journal, 2016-11
Effects of Statin Therapy in Patients with Systemic Lupus Erythematosus.
Annals of the rheumatic diseases, 2011-05
Lupus Atherosclerosis Prevention Study (LAPS).
Atherosclerosis, 2015 Aug 28
Statin reduces mortality and morbidity in systemic lupus erythematosus patients with hyperlipidemia: A nationwide population-based cohort study.
JAMA ophthalmology, 2014-12
The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy.
Can J Ophthalmol,
Retinal toxicity of high-dose hydroxychloroquine in patients with chronic graft-versus-host disease.
J Am Acad Dermatol, 2016 Feb 03
The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2008-10
Prophylactic antibiotic usage for Pneumocystis jirovecii pneumonia in patients with systemic lupus erythematosus on cyclophosphamide: a survey of US rheumatologists and the review of literature.
Clin Rheumatol, 2006 Dec 21
Infection-related morbidity and mortality in patients with connective tissue diseases: a systematic review.
Blood, 2015 May 13
A novel triple therapy for ITP using high-dose dexamethasone, low-dose rituximab, and cyclosporine (TT4).
Blood, 2009 Nov 06
Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura.
Annals of the rheumatic diseases, 2011-10
Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus.
Arthritis Rheum,
Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis.
Rheumatol Int, 2019 Apr 30
Indications for bone marrow examinations in rheumatology.
Clin Exp Rheumatol, 2012 Sep 25
Indications for bone marrow examination in autoimmune disorders with concurrent haematologic alterations.
Wien Klin Wochenschr,
[Rationale for bone marrow examination in patients with inflammatory rheumatic diseases].
Kidney international, 2019-01
A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.
J Rheumatol, 2006 Jul 01
Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares.
Semin Arthritis Rheum,
Treatment of severe neutropenia due to Felty's syndrome or systemic lupus erythematosus with granulocyte colony-stimulating factor.
Lupus, 2008-08
Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report.
Arthritis Rheumatol, 2021 Aug 12
Predicting the Risk of Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: A Chinese Systemic Lupus Erythematosus Treatment and Research Group Cohort Study.
Int J Clin Pract, 2021 Mar 24
Effect of COVID-19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey.
Mod Rheumatol, 2021 Feb 09
QTc interval prolongation in patients with systemic lupus erythematosus treated with hydroxychloroquine.
Heart Rhythm, 2020 Jun 28
Effects of hydroxychloroquine treatment on QT interval.
Blood,
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance.
Arthritis care & research, 2018-03
Examination of Hydroxychloroquine Use and Hemolytic Anemia in G6PDH-Deficient Patients.
J Clin Rheumatol, 2020 Sep 18
Association of Hydroxychloroquine use and Hemolytic Anemia in Patients With Low Levels of Glucose-6-Phosphate Dehydrogenase.
Cureus, 2020 Aug 02
A Study on the Relevance of Glucose-6-Phosphate Dehydrogenase Level Screening in Patients with Rheumatic Diseases Prior to Initiating Treatment With Hydroxychloroquine.
The New England journal of medicine, 2003-10-16
Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
Lupus, 2007
Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus.
J Allergy Clin Immunol, 2020 May 22
Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype.
Nat Rev Rheumatol,
Diagnostic role of anti-dsDNA antibodies: do not forget autoimmune hepatitis.
Kidney international, 2009-12
A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis.
Clinical journal of the American Society of Nephrology : CJASN, 2010-07
Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study.
Journal of the American Society of Nephrology : JASN, 2010-08
Comparison of different measures of urinary protein excretion for prediction of renal events.
Am J Kidney Dis, 2016 Sep 16
Timed Urine Collections for Albumin and Protein: "The King Is Dead, Long Live the King!".
J Rheumatol, 2004 Aug
Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis.
Arthritis & rheumatology (Hoboken, N.J.), 2015-07
Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.
Arthritis Rheum,
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes.
Lancet, 2021 May 07
Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.
Autoimmunity reviews, 2009-02
The risk of ultraviolet radiation exposure from indoor lamps in lupus erythematosus.
Arthritis and rheumatism, 2013-07
Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.
Arthritis Rheumatol, 2021 Mar 24
Long-Term Safety and Efficacy of Anifrolumab in Adults With Systemic Lupus Erythematosus: Results of a Phase II Open-Label Extension Study.
Rev Med Interne, 2016 Oct 13
[Blood concentration of hydroxychloroquine in systemic lupus erythematosus care: Usefulness and limits].
Arthritis Care Res (Hoboken), 2021 Mar 30
Clinical Significance of Monitoring Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis.
JAMA Dermatol,
Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus: a case-control study.
Mod Rheumatol, 2020 Sep 17
Anifrolumab, a monoclonal antibody to the type I interferon receptor subunit 1, for the treatment of systemic lupus erythematosus: an overview from clinical trials.
Ann Rheum Dis, 2014 Feb 13
The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: data from a multiethnic Latin American cohort.
Ann Rheum Dis, 2019 Jan 04
Organ damage in patients treated with belimumab versus standard of care: a propensity score-matched comparative analysis.
Ann Rheum Dis, 2014 Apr 16
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