How do you manage a DOAC if interested in testing for lupus anticoagulant?

Testing for anti-phospholipid antibodies encompasses two broad categories of testing. One is an ELISA based (aka solid phase) set of tests that include anti-cardiolipin and anti-beta 2 glycoprotein I antibodies. ELISA assay are not affected by DOACs. For the second lupus anticoagulant (aka fluid pha...

Agree with Dr. @Dr. First Last; the serologic tests for AcL and anti-B2GPI antibodies are not affected by anticoagulants whereas the functional tests, e.g., the LAC (lupus anticoagulant), etc., will look positive if done while the patient is receiving them, any anticoagulant but not aspirin or HCQ. ...

LA Testing in the setting of DOACs, Heparin or Vitamin K antagonist.

# DOACs

Some labs try to remove DOACs via charcoal. Inhibitors of apixaban, rivaroxaban, and dabigatran are available, but not commercially available to use in laboratories. So they can give rise to false positive LA tests in bo...

Agree with my colleagues.

ELISA tests are not affected by DOAC.

For LAC testing, I hold it for 48 hours before test. Since it requires interruption of anticoagulants, I wait at least 6-8 weeks before testing for LAC unless clinical suspicion is very high.