How does the updated classification system of gliomas impact your recommendations for radiation?

Topics: Radiation Oncology • Neuro-Oncology • Medical Oncology

Answer from: Radiation Oncologist at Academic Institution

Minesh Mehta and @Rupesh Kotecha, Miami Cancer Institute In 2021, the World Health Organization (WHO) introduced significant new changes to the classification of tumors of the central nervous system (CNS) in their 5th edition (WHO CNS5) (Louis et al., PMID 34185076). This step was the first of ...

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Radiation Oncologist at University of Rochester
Dr. @Minesh P. Mehta – this is an amazing su...

Radiation Oncologist at Center for Neurosciences
@Minesh P. Mehta Thank you for the detailed explan...

Medical Oncologist at Joliet Oncology Hematology Associates
Thank you for a detailed thoughtful commentary.

Answer from: Radiation Oncologist at Academic Institution

The issue of IDH wild type malignant glioma without TERT promoter mutations remains one of the vexing issues with the current classification. It is estimated that perhaps about 20% of GBMs lack genetic alterations in IDH (hence IDH wild-type) and also the TERT promoter (hence TERTp wild-type). An in...

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Radiation Oncologist at Washington University School of Medicine
@Minesh P. Mehta, thank you for sharing your insig...

Answer from: Medical Oncologist at Community Practice

ASTRO guidelines just published https://www.practicalradonc.org/article/S1879-8500(22)00144-8/fulltext#relatedArticles.

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