How should we think about endocrine resistance in patients with inherited germline mutations such as BRCA, CHEK2, etc.?  

Should these patients have a different threshold for utilizing a CDK4/6 inhibitor in the front line metastatic or as part of adjuvant therapy, or SERDs where eligible?

Answer from: Medical Oncologist at Community Practice
Medical Oncologist at NYU Winthrop Hospital
Great review
Medical Oncologist at NorthEast Onc Assocs
Great summary and guidance in this patient populat...
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