How would you approach a young person with JAK2 V617F positive essential thrombocytosis with otherwise low risk features?

Topics: Medical Oncology • Myeloproliferative Neoplasms • Hematology • Pediatric Hematology

Would you get bone marrow biopsy periodically? Would your approach change based off specific age or platelet count?

Answer from: at Academic Institution

The first question in this situation is what is the JAK2 V617F neutrophil quantitative allele burden (NAB)? It must be less than 50% for a diagnosis of essential thrombocytosis (ET). Second, are we dealing with a man or woman? Men with so-called "ET" are much more likely than women to develop myelof...

Comments

at Kaiser Permanente, Los Angeles Med Center
Thank you so much for your thoughtful and detailed...

Medical Oncologist at Pasco Hernando Onc Assoc
Thank you, Dr. @Jerry Spivak. Really helpful insig...

Medical Oncologist at University of Iowa Hospitals & Clinics
@Jerry Spivak, is NAB tested from peripheral blood...

at Johns Hopkins University
There is no difference between measurements of JAK...

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