How would you manage a pre-menopausal woman with extranodal marginal zone lymphoma confined to the bladder wall?

Given pelvic RT is likely to induce ovarian dysfunction/menopause, would you consider systemic options?

Answer from: Radiation Oncologist at Academic Institution

Marginal Zone Lymphoma (MZL) when localized is curable in most instances with modest doses of RT (24-30 Gy), perhaps even less when the primary site is the orbit. It typically responds to rituximab but relapses occur in most cases. Therefore, definitive RT is the treatment of choice in the great maj...

Comments

Radiation Oncologist at Texas Oncology-Arlington Cancer Center North
For marginal zone lymphoma that does not respond t...

Radiation Oncologist at Duke University Medical Center
In patients who don't respond to or relapse follow...

Answer from: Medical Oncologist at Academic Institution

The lesion is described as "confined to the bladder wall". No strong epidemiological data links bladder wall marginal zone lymphoma with a particular underlying infection, a situation that is not uncommon in other extranodal sites of disease. I agree with the concern about the use of radiation thera...

Please select the option that best describes you:

How would you manage a pre-menopausal woman with extranodal marginal zone lymphoma confined to the bladder wall?

Related Questions