How would you manage new symptomatic brain metastases (10-15) in a young woman with HER2+ metastatic breast cancer?

Controlled extracranial disease on trastuzumab+pertuzumab for 2 years. Treatment options include switching systemic rx (T-Dxd, tucatinib) or WBRT. Not a candidate for SRS or neurosurgery.

Answer from: Radiation Oncologist at Academic Institution

A lot of nuance to answering this on a per-patient basis.First question, how symptomatic? (As in, are there bulky mets that we should be considering surgical management upfront plus this also guides my discussion about whole brain vs systemic)If not acutely symptomatic and requiring a crani/resectio...

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Radiation Oncologist at Stroger Hospital
Absolutely agree

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How would you manage new symptomatic brain metastases (10-15) in a young woman with HER2+ metastatic breast cancer?

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