How would you treat a locally advanced rectal squamous cell cancer with vaginal invasion?
Additional details include 7 cm, cT4N1, basaloid squamous cell cancer with invasion into the vagina over about 5 cm. Denies pain or difficulty passing BMs, as well as vaginal pain and bleeding.
2 Answers
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Radiation Oncology · Washington University School of Medicine
Answered on
If the anterior wall of the vagina is free (i.e., the 5 cm refers to the cephalo-caudad length of the tumor), and this proves to be a case of a high grade but potentially resectable (assuming adequate response to preoperative tx) T4 rectal cancer. I've treated cases with exactly this histology and p...
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Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
I would get p16/HPV status and pDL1 testing. It could be vaginal cancer invading the rectum. I would treat with concurrent chemoRT with cisplatin-based chemo, with EBRT and a boost to 70+ Gy, then reassess for any salvage based on response.
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