If a patient with non-metastatic prostate cancer is found to have a BRCA mutation, should this influence treatment recommendations for local therapy?

While there are no randomized trials to address this question, one prospective, non-randomized study of BRCA2 carriers with localized prostate cancer suggested improved outcomes with lower relapse rates in men treated with radical prostatectomy as opposed to radiation therapy. See: Castro et al., Journal of Clinical Oncology 2013

While this is a small study and subject to confounding and bias, this is the best data available and suggests relative radioresistance in BRCA2 mutated localized prosta...

Few I have treated had aggressive high grade cancer with one having nodal disease and poor outcome