If using durvalumab/tremelimumab for advanced HCC, must the tremelimumab be given with the first cycle of durvalumab?

Topics: Gastrointestinal Cancers • Medical Oncology • Hepatocellular Carcinoma • Journal Club ft. NEJM publications

Is there a difference in efficacy if dose is given later point during the course of therapy?

Answer from: Medical Oncologist at Academic Institution

Understandably, one may be nervous about the use of tremelimumab because of prior experience with other CTLA4 checkpoint inhibitors like ipilimumab. With tremelimumab being given only once, such concerns would be less or dissipate all together. Sure, durvalumab plus tremelimumab should be given toge...

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Medical Oncologist at Rutgers Cancer Institute of New Jersey
Thanks @Ghassan. Obviously, we should attempt to f...

Answer from: Medical Oncologist at Academic Institution

I do my best to follow the clinical data and would dose medications as they were developed in the context of clinical trials.

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