Is day 43 cisplatin 100mg/m2 needed after completion of RT in case of a delay related to neutropenia for locally advanced head and neck cancer?
Should the dose still be given after completion of RT?
Answer from: Medical Oncologist at Academic Institution
Based on the retrospective post hoc analysis from RTOG 0129, two cycles of HD cisplatin in the accelerated fraction radiation treatment arm and two cycles of HD cisplatin in the standard fraction radiation arm were equivalent to 3 cycles of HD cisplatin when administered with RT. (Nguyen-Tan et al.,...
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Answer from: Medical Oncologist at Academic Institution
Cisplatin added radiation for the purpose of radiosensitization should only be administered during radiation and studies indicate no benefit but added toxicity with a 3rd cycle.