Is day 43 cisplatin 100mg/m2 needed after completion of RT in case of a delay related to neutropenia for locally advanced head and neck cancer?
Should the dose still be given after completion of RT?
Community PollStarted
Do you give the final dose of 100mg/m2 cisplatin after RT is completed in a H&N patient who had chemo treatment delays?
224 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet MemberInvited Expert
Medical Oncology · University of Michigan Medical School
Answered on
Based on the retrospective post hoc analysis from RTOG 0129, two cycles of HD cisplatin in the accelerated fraction radiation treatment arm and two cycles of HD cisplatin in the standard fraction radiation arm were equivalent to 3 cycles of HD cisplatin when administered with RT. (Nguyen-Tan et al.,...
Join for free or sign in to see the full answer
Mednet Member
Medical Oncology · Vanderbilt
Answered on
Cisplatin added radiation for the purpose of radiosensitization should only be administered during radiation and studies indicate no benefit but added toxicity with a 3rd cycle.
Join for free or sign in to see the full answer