What are the indications to treat Dupuytren's disease with radiation?

I would not offer any radiation therapy after a surgical procedure for Dupuytren's contracture. Should the patient develop recurrent nodules that progress more than 6 months following surgery, then I would consider definitive split-course electron beam therapy to deliver 30 Gy at 3 Gy per fraction w...

My only experience has been in patients who have previously undergone surgery and recurred, as per @Dr. First Last's recommendations. The most popular fractionation schedule used in Germany (where much of the research on XRT for benign diseases comes from) is a split-course regimen where 5 fractions...

Patients who require surgery for contracture have an extremely high recurrence rate. Hence, I wait about 2 weeks for healing, then deliver 250 cGy x 10 with an electron beam, and have had a high success rate in preventing a recurrence. No split course.

James Pelton
Bellevue, WA

Radiotherapy is most effective for early, progressive disease—before fixed flexion contracture develops. I frame indications using the Tubiana staging system, which grades total finger flexion deficit across the MCP and PIP joints:

DEPART is researching whether radiotherapy is helpful in maintaining a flat hand (prevention) or following a minimally invasive procedure such as an aponeurotomy (adjuvant). Neither role has been definitively proven, so the results of DEPART will be helpful to inform our understanding of the magnitu...