What is the appropriate radiation volume for a stage III, group III unresectable embryonal rhabdomyosarcoma originating from the bladder?
When the original tumor extent is substantial (displaces normal abdominopelvic organs), but responds well to therapy (i.e. as of week 12) - How would you target the pretherapy extent without unnecessarily overtreating the previously displaced organs?
i.e. Should your CTV1 encompass the current bladder tumor plus a 1 cm expansion w/o the displaced bowel volume, OR should it include the entire pre-chemotherapy bladder tumor extent (which necessitates irradiating large amounts of normal bowel)?
Are there potentially infiltrated spaces which should be covered beyond the 1cm expansion on the post-therapy extent which were likely involved pre-therapy?
1 Answer
Mednet Member
Radiation Oncology · University of North Carolina Chapel Hill School of Medicine
Answered on · Updated on
For bladder/prostate or pelvic tumors that displaced a significant amount of bowel which has then returned to its normal anatomic position after chemotherapy, GTV1 and CTV1 will be defined by the prechemotherapy extent of tumor excluding the component that is now normal intra-abdominal components (i...
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