What is your preferred third-line therapy for metastatic colon cancer, RAS-WT, MSS, low TMB, with no targetable alterations?
Are you using fruquintinib, regorafinib, or trifluridine + tipiracil + bev?
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What is your preferred third line therapy for colon cancer?
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2 Answers
Mednet MemberInvited Expert
Medical Oncology · Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
Answered on
My preferred treatment in this scenario is trifluridine-tipiracil plus bevacizumab. This is based on the favorable side-effect profile of this regimen (compared to alternatives) and the evidence from the SUNLIGHT trial, which showed that bevacizumab plus trifluridine-tipiracil was superior to triflu...
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Mednet MemberInvited Expert
Medical Oncology · Henry Ford Cancer Institute (HFCI)
Answered on
If no clinical trial is available, then Lonsurf, Avastin, or at times, rechallenge with an anti-EGFR may be used in first line.
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