What is your strategy for ovarian suppression if unable to achieve goal estradiol levels with leuprolide 3.75mg monthly dose?

Monthly therapy rarely fails to induce adequate suppression. The choice of options will depend on whether the patient planned permanent or only temporary suppression AND the risk of recurrence of the cancer. If she will accept permanent suppression and has high risk disease, oopherectomy would be th...

As shown in the SOFT-EST substudy, lack of ovarian function suppression with the use of GnRHa can be observed in up to 20% of the patients receiving this treatment. Main risk factors appear to be no prior exposure to chemotherapy, very young age and high body mass index. Although the lack of ovarian...

I agree with @Dr. First Last—if the patient has no desire for future pregnancy, I usually advocate for BSO. If future pregnancy is a possibility, I switch to tamoxifen or tamoxifen +OFS.