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What would your next line treatment be for a patient previously treated with repeat resection, craniospinal irradiation, and initial cisplatin/vincristine/CCNU with medulloblastoma?

What would be your next treatment for a young adult patient with medulloblastoma refractory to repeat resection, craniospinal irradiation, and initial cisplatin/vincristine/CCNU? What is your preferred option if the patient doesn't have access to oral chemotherapies due to insurance barriers?
1 Answer
Mednet Member
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Pediatric Hematology/Oncology · C. S. Mott Children’s Hospital, University of Michigan
Answered on

As you will agree, this is an extremely unfortunate situation. I am assuming this patient has progressed either while on therapy or soon after completion? Depending on his age, a potential option is to enroll him on any available clinical trials. PBTC58 study uses intrathecal omburtumab along with c...

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