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Which patients with primary, early-stage NSCLC would you utilize immunotherapy in conjunction with SBRT?

This post refers to the recently published RCT by Chang et al., PMID 37478883 investigating lung SBRT with vs. without 4 months of nivolumab for early stage, primary NSCLC. What subset of patients may be appropriate for this approach now?
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For which patients with primary, early-stage NSCLC would you utilize immunotherapy in conjunction with SBRT?

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1 Answer
Mednet Member
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Radiation Oncology · University of Pennsylvania Health System
Answered on · Updated on

The trial from Chang et al., PMID 37478883 testing SBRT +/- IO for early-stage NSCLC was a randomized phase II trial. Although very exciting results, it's not a phase III trial and does not technically change management. IO agents are not FDA-approved in this setting yet! There are at least 2 phase ...

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