Which regimen would you recommend for a young patient with node-positive, triple-positive breast cancer with significant anthracycline-induced cardiomyopathy?

Question inspired by the case of a young woman with LVEF 20-25%, asymptomatic.

Answer from: Medical Oncologist at Academic Institution

I would consider the NeoPact regimen, consisting of 6 cycles of docetaxel, carboplatin, and pembrolizumab, which is currently being directly compared to the Keynote-522 regimen in the SCARLET trial. Given some immune-related cardiac risks of pembrolizumab, I would strongly recommend that the patient...

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Which regimen would you recommend for a young patient with node-positive, triple-positive breast cancer with significant anthracycline-induced cardiomyopathy?

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