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Would you consider lymphovascular invasion at the margin to be a positive margin in breast cancer surgery?

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Mednet Member
Mednet Member
Radiation Oncology · Varian Medical Systems/Allegheny health network

LVI is an independent risk factor for local relapse despite adequate treatment. That being said, we don’t chase LVI to get negative margin as it is non contiguous involvement and not contiguous process which warrants any reexcision.

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Mednet Member
Mednet Member
Surgical Oncology · Virginia Commonwealth University School of Medicine

There is no evidence to support LVI as a positive margin. One must presume that if you have LVI, that supports a systemic spread of disease, not local (increased risk for positive nodes, etc.). I would not re-excise for LVI at a margin.

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Would you consider lymphovascular invasion at the margin to be a positive margin in breast cancer surgery? | Mednet