Would you provide TDM1 or capecitabine for residual disease in HR negative patients with HER2 positivity based on copy number alone?

For patients with hormone negative breast cancer and HER2 positive only by copy number, do you give TDM1 for residual disease or capecitabine?

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Which treatment would you provide for this group of patients?

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1 Answer

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Medical Oncology · Indiana University School of Medicine

Answered on

It is not clear from the question what is meant by "copy number alone." To be HER2 positive by copy number alone is a copy number equal or greater than 6.0 (unless IHC 0 or 1 + with a ratio also < 2.0, in which case the tumor is HER2 negative). If the copy number is between 4 and 6, but the ratio is...

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