Would you provide TDM1 or capecitabine for residual disease in HR negative patients with HER2 positivity based on copy number alone?

Topics: Breast Cancer • Medical Oncology • Breast Cancer, Non-metastatic

For patients with hormone negative breast cancer and HER2 positive only by copy number, do you give TDM1 for residual disease or capecitabine?

Answer from: Medical Oncologist at Academic Institution

It is not clear from the question what is meant by "copy number alone." To be HER2 positive by copy number alone is a copy number equal or greater than 6.0 (unless IHC 0 or 1 + with a ratio also < 2.0, in which case the tumor is HER2 negative). If the copy number is between 4 and 6, but the ratio...

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Medical Oncologist at R and B Lewis Cancer Care Center
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