Would you recommend anticoagulation prophylaxis for a pediatric patient admitted with COVID-19?

COVID-19 disease in children seems to be less severe than adults based on the current literature and our personal experience at Children's Hospitals. Among adults, the coagulopathy is beginning to be described with elevated inflammatory markers and other markers of coagulation activation, including D-dimers. I have not seen data in children systematically looking at these parameters at all stages of the disease.

In the largest experience in children published from Wuhan, China, more than 90% of the 2,143 children diagnosed with laboratory verified or clinically diagnosed COVID-19 had asymptomatic, mild, or moderate disease. Of the remainder, 5.2% had severe disease and 0.6% had critical disease. According to a disease classification proposed...

If you are interested in this question, Dr. Neil Goldenberg from Johns Hopkins All Children's Hospital, Tampa, FL, is recruiting sites to submit a clinical trial addressing this topic. Please let me know, thanks.

The American Society of Hematology has provided some information to answer this question: https://www.hematology.org/covid-19/covid-19-and-vte-anticoagulation