Would you recommend consolidative radiation therapy for advanced stage bulky Hodgkin's lymphoma with a delayed complete response after 6 cycles of A-AVD chemotherapy?

I suppose I have three comments about this question.

First, the sensitivity (percentage of true positives) and specificity (percentage of true negatives) are generally higher than the positive predictive value (true positives/all positives) for end-of-treatment PET-CT in lymphoma. In one study, the PPV in this setting was 64% when a Deauville 4 or 5 scan was considered a positive test (Fallanca et al., PMID 27154522). Therefore, around 1/3 of positive PET-CTs are false positives (there is no resi...