Would you recommend early empirical anti-mold therapy for patients with severe influenza pneumonia admitted to the ICU to reduce the incidence of influenza-associated pulmonary aspergillosis?

Although this is a known complication, I would not place someone on mold prophylaxis given the lack of supporting data, the rarity of the complication, and the fact that—when considered early—it can usually be identified based on signs and symptoms suggestive of invasive mold infection. Prophylaxis may be reasonable in very high-risk situations, such as in patients with significant underlying lung disease and prior cultures indicating mold colonization, but these scenarios are uncommon.

No, I don't see it frequently.