General Infectious Disease

Questions discussed in this category

What is your approach to treatment of patients with fulminant C difficile infection who required ileostomy creation or colectomy?

Is there a role for oral vancomycin in these patients, or is oral vancomycin redundant if other routes of administration are being used (i.e intracolo...

1 Answer available

Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?

2 Answers available

Do you recommend antibiotic prophylaxis for an ESKD patient with a tunneled dialysis catheter who is planned for a dental procedure?

2 Answers available

For how long would you treat Klebsiella aerogenes folliculitis of the face manifesting as a cystic lesion?

Would you combine antibiotics with isotretinoin?

1 Answer available

Do you prescribe linezolid to patients who are concomitantly on an SSRI?

7 Answers available

How long would you treat a patient with recent history of TAVR presenting with E faecalis bacteremia with unclear source with TEE showing thickened valves but no obvious vegetation?

2 Answers available

How long do you treat an isolated bacterial liver abscess which has either undergone percutaneous drainage or for which an indwelling drain is placed?

2 Answers available

What is your approach to the use of Paxlovid for patients with risk factors for severe Covid-19 infection but who have received SARS-CoV-2 vaccines in light of the EPIC-SR trial findings?

EPIC-SR Trial

2 Answers available

What is your approach to recurrent asymptomatic bacteriuria in pregnancy for patients without personal history of recurrent UTIs or pyelonephritis?

Assuming patient already received an initial course of antibiotic treatment in response to a positive urine culture during routine screening early in ...

2 Answers available

What is your approach to duration of systemic antibiotics for treatment of isolated bacterial endophthalmitis in the absence of bacteremia or other deep-seated metastatic foci of infection?

1 Answer available

What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?

Would it be safe to resume and if so, when?

1 Answer available

What is your approach to a patient with undetectable MMR titers checked prior to or during immunosuppression and a history of MMR vaccination in childhood?

Is there a role for booster vaccination and if so, how do you approach the timing when a patient is already on a biologic for immunosuppression?

1 Answer available

How do you treat a patient with a gram-negative infection with resistance to imipenem but sensitivity to meropenem and negative for Carbapenem resistant organism by xpert Carba-R-assay?

1 Answer available

Do you add gentamicin when treating prosthetic valve endocarditis secondary to viridans group Streptococcus with a penicillin-intermediate isolate (MIC >0.125 - <0.5)?

1 Answer available

Have you incorporated the use of steroids for patients with severe community-acquired pneumonia?

In light of published data from the CAPE COD trial...

1 Answer available

Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?

1 Answer available

Is there a role for chronic suppressive oral or inhaled therapy for recurrent Burkholderia cepacia pneumonia causing frequent hospitalizations in a patient with severe bronchiectasis with or without underlying cystic fibrosis?

3 Answers available

In addition to ampicillin, is there any benefit to the addition of either gentamicin or bactrim when treating a patient with listeria meningitis?

2 Answers available

Do you transition to oral antibiotics to treat uncomplicated Staphylococcus aureus bacteremia after patients have improved with intravenous antibiotic therapy?

3 Answers available

Have you applied the POET trial to clinical practice?

1 Answer available

How long do you continue antibiotics after cholecystostomy tube placement for acute cholecystitis?

Since the COVID-19 pandemic, increasingly we see management of acute cholecystitis with cholecystostomy tubes as opposed to surgery, even amongst pati...

1 Answer available

What duration of therapy do you use for treatment of Legionella pneumonia in an immunocompetent host without associated empyema or extrapulmonary infection?

2 Answers available

Do you add adjunctive gentamicin and/or rifampin for treatment of prosthetic valve Staphylococcus aureus endocarditis?

1 Answer available

Is there a role for beta-lactams as step-down oral therapy for uncomplicated gram-negative bacteremia?

If so, what antibiotic regimens do you use?

6 Answers available

Do you take into consideration a patient's serum albumin level in your decision to use ertapenem?

1 Answer available

For how long do you treat an early spinal hardware infection secondary to MSSA after operative washout and retention of hardware?

1 Answer available

Do you treat Stenotrophomonas maltophilia bacteremia with combination therapy and if so, what is your preferred combination of antibacterials?

1 Answer available

For how long do you treat uncomplicated CRE bacteremia in an immunocompetent patient?

1 Answer available

Would you consider stepping down from an echinocandin to azole therapy prior to the end of an initial six-week course for fluconazole-susceptible Candida albicans endocarditis in the absence of valve surgery?

1 Answer available

Papers discussed in this category

Circulation, 2015 Sep 15

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

The Annals of thoracic surgery, 2017 Feb 04

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies.

European heart journal, 2023 Oct 14

2023 ESC Guidelines for the management of endocarditis.

The Annals of thoracic surgery, 2016-06

Rifampin for Surgically Treated Staphylococcal Infective Endocarditis: A Propensity Score-Adjusted Cohort Study.

JAMA network open, 2022 Dec 01

Association of Linezolid With Risk of Serotonin Syndrome in Patients Receiving Antidepressants.

International journal of antimicrobial agents, 2023 Jun 08

Dose optimisation of linezolid in critically ill patients based on a population pharmacokinetic model: A two-centre prospective interventional study.

Pharmacy (Basel, Switzerland), 2023 Nov 20

The Association of Serotonin Toxicity with Combination Linezolid-Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis.

International journal of antimicrobial agents, 2023 May 07

Real-world evaluation of linezolid-associated serotonin toxicity with and without concurrent serotonergic agents.

JAMA network open, 2024 Jan 02

Early Switch From Intravenous to Oral Antibiotics for Patients With Uncomplicated Gram-Negative Bacteremia.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2023 Nov 24

Treatment guidelines for multidrug-resistant Gram-negative microorganisms.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2023 Oct 26

In vitro activity of cefiderocol and other newly approved antimicrobials against multi-drug resistant Gram-negative pathogens recovered in intensive care units in Spain and Portugal.

EClinicalMedicine, 2022 Dec 01

Duration of antibiotic treatment for Gram-negative bacteremia - Systematic review and individual participant data (IPD) meta-analysis.

Journal of clinical pharmacy and therapeutics, 2020 Sep 27

Short-course versus long-course antibiotic treatment in patients with uncomplicated gram-negative bacteremia: A systematic review and meta-analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Sep 13

Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized Controlled Trial.

European heart journal, 2023 Oct 25

Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2023 May 11

Choosing patients over placebos: oral transitional therapy vs. IV-only therapy for bacteraemia and infective endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Jul 26

Attainment of Target Antibiotic Levels by Oral Treatment of Left-Sided Infective Endocarditis: A POET Substudy.

Infectious diseases and therapy, 2022 May 03

Legionnaires' Disease: Update on Diagnosis and Treatment.

American journal of respiratory and critical care medicine, 2019 Oct 01

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 18

Considerations and Concerns regarding the use of Ertapenem in Patients with Hypoalbuminemia: is it Truly Inappropriate?

The Lancet. Infectious diseases, 2024 Jan 17

Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.

Journal of the American College of Cardiology, 2023 Jan 31

Infective Endocarditis After Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review.

JACC. Cardiovascular interventions, 2022 Jun 13

Long-Term Follow-Up of Hypoattenuated Leaflet Thickening After Transcatheter Aortic Valve Replacement.

JACC. Cardiovascular imaging, 2017 Aug 16

Diagnosis of Infective Endocarditis After TAVR: Value of a Multimodality Imaging Approach.

The New England journal of medicine, 2018 Aug 28

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 11

Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study.

N Engl J Med, 2023 Mar 21

Hydrocortisone in Severe Community-Acquired Pneumonia.

Ophthalmology. Retina, 2019 Mar 21

International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1.

Retina (Philadelphia, Pa.), 2021 Feb 01

VISUAL OUTCOME OF EARLY VITRECTOMY AND INTRAVITREAL ANTIBIOTICS IN ACUTE POSTSURGICAL AND POSTINTRAVITREAL INJECTION ENDOPHTHALMITIS: European Vitreo-Retinal Society Endophthalmitis Study Report Two.

Archives of ophthalmology (Chicago, Ill. : 1960), 1995 Dec

Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group.

The New England journal of medicine, 2024 Apr 04

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19.

Circulation, 2008 Jun 09

Bacteremia associated with toothbrushing and dental extraction.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 1999 May-Jun

Prophylactic antibiotic therapy prior to dental treatment for patients with end-stage renal disease.

Nephrology (Carlton, Vic.), 2004 Jun

Antibiotic prophylaxis in dialysis patients undergoing invasive dental treatment.

General Infectious Disease

Questions discussed in this category

Papers discussed in this category

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