Would you stop azathioprine in a patient with ANCA vasculitis who has been in long term remission on azathioprine, but has a new diagnosis of lung cancer requiring initiation of immunotherapy?

Topics: Immunotherapy • Immune-related adverse events • Rheumatology • Vasculitis • ANCA Vasculitis • Pulmonology

Answer from: at Academic Institution

Data about the effect of immunosuppression on the efficacy of immune checkpoint inhibitors suggests that there is a negative of effect of being on immunosuppression at the time of ICI initiation on tumor response. So if the patient really has been clinically stable for a long time there are a few op...

Comments

at Hudson Hospital & Clinic
Much thanks!

Answer from: at Community Practice

Completely agree with @Dr. @Cappelli above. No high-powered prospective studies to inform our decision. Before answering on azathioprine in this context, would want more information about the AAV diagnosis first: localized to upper resp tract or was there involvement of lung+ renal+/- other or...

Related Questions