Would you stop azathioprine in a patient with ANCA vasculitis who has been in long term remission on azathioprine, but has a new diagnosis of lung cancer requiring initiation of immunotherapy?

Data about the effect of immunosuppression on the efficacy of immune checkpoint inhibitors suggests that there is a negative of effect of being on immunosuppression at the time of ICI initiation on tumor response. So if the patient really has been clinically stable for a long time there are a few op...

Completely agree with @Dr. @Dr. First Last above. No high-powered prospective studies to inform our decision.

Before answering on azathioprine in this context, would want more information about the AAV diagnosis first:

• localized to upper resp tract or was there involvement of lung+ renal+/- other or...