Questions discussed in this category

Vasculitis activity has been assessed with serial CTA of the chest and head/neck. She has existing right axillary artery disease and new areas of invo...

Other manifestations improved (renal function has stabilized, fatigue, arthritis, and LCV have resolved). Ophthalmologist has controlled the uveitis u...

In a patient for whom rituximab is the best option for their disease management. 

At what CD 19/20 level do you redose? Is this lab dependent?  Do you also use these levels to instruct patients when to get vaccinated?

Would the checkpoint inhibitor still work if blocking only that portion of the inflammatory cascade as opposed to more global blockade with steroids?

What are your primary and secondary agents?

Is there role for IVIG? Would you alter the dose or time course of steroid therapy?

In your experience, are there specific disease manifestations in which HLAB51 is particularly helpful?

Other than inflammatory markers and following symptoms/exam, do you need any other specific monitoring for progression to systemic disease? 

Additionally, what is the current role for temporal artery ultrasound in workup for GCA?

Do you obtain vascular imaging routinely in these cases, and if so, do you use cross-sectional or invasive angiography?

Small study in pediatric PACNS have evaluated this as a potential marker (Cellucci et al., PMID 22740622)

There are multiple difficulties that could be seen: steroids can precipitate a sickle cell crisis, vasculitis and sickle cell can produce similar clin...

E.g., MPO vs PR3, newly diagnosed vs relapsed, renal involvement. Acknowledge that the ADVOCATE study was not powered to detect these differences, but...

Given the slow recovery of nerve damage, what would you expect to see on a repeat EMG after treatment? Continued denervation or just sequelae of past ...

What if the patient has MGUS? Do patients with type 1 cryoglobulins need a bone marrow biopsy as part of the work up?

How would you label such a patient?  Would you treat differently if they have poor functional status?

This question is part of a collaboration with RheumMadness and is in reference to: Pathogenic ANCARAVE Trial

Papers discussed in this category

The New England journal of medicine, 2010-07-15

Medicine (Baltimore),

The New England journal of medicine, 2010-07-15


Ann. Rheum. Dis., 2018 Apr 25

Ann. Rheum. Dis., 2017 May 25

Ann. Rheum. Dis., 2018 May 03

Medicine, 1976-05

Arthritis and rheumatism, 2010-01

J. Rheumatol., 2019 Sep 01

Annals of the rheumatic diseases, 2009-03

BJR Case Rep, 2018 Sep 08

Ann Intern Med, 2020 Sep 22

Curr Rheumatol Rep, 2020 Oct 16

N Engl J Med,

Lancet, 2016 Mar 04

JAMA network open, 2018-11-02

Rheumatol Int, 2020 Sep 18

The New England journal of medicine, 2017-05-18

Kidney international reports, 2018-03

N Engl J Med, 2020 Feb 13

Rheumatology (Oxford),

The Journal of rheumatology, 2012-02

Rheumatology (Oxford, England), 2011-12

Nat Rev Neurol,

Nat Rev Dis Primers, 2018 Aug 02

N Engl J Med, 2021 Feb 18

Rheumatology (Oxford),

Ann Intern Med,

Ann Rheum Dis, 2011 Nov 29

Annals of internal medicine, 1994-06-15

Front Neurol, 2019 Jun 06

Curr Opin Rheumatol,

Arthritis Rheum,

Seminars in arthritis and rheumatism, 2012-06

Arthritis Rheumatol, 2021 Jul 08

Ann Rheum Dis, 2019 Jul 03

Radiographics : a review publication of the Radiological Society of North America, Inc, 2001

International journal of clinical rheumatology, 2010

Mayo Clin Proc,

Seminars in arthritis and rheumatism, 2016-02

Bull Soc Ophtalmol Fr,

Am J Hum Genet, 2021 Jan 7

Ann Rheum Dis, 2021 Jul 02

RMD Open, 2021 Sep

J Dermatol,

Arthritis Rheum,

J Am Acad Dermatol, 2021 Jul 02

Arthritis Care Res (Hoboken), 2020 May 19

J Rheumatol, 2021 Feb 15

Rheumatology (Oxford),

Eur J Cancer, 2021 Sep 15

Thorac Cancer, 2020 Feb 11

The New England journal of medicine, 2013-08-01

N Engl J Med,

N Engl J Med,

Rheumatol Int, 2014 Jun 05

Heart, 2021 Feb 16

Arthritis Rheumatol, 2019 Nov 04

Arthritis Rheumatol, 2022 Jun 20

Journal of vascular surgery, 2006-01

Rheumatology (Oxford), 2022 Jul 06

Clin Exp Rheumatol, 2022 Nov 02

Mayo Clinic proceedings, 2018-11

Kidney Int, 2017 May 12

Arthritis Rheumatol, 2020 Sep 6