Based on the VESPER trial data, do you recommend the full 6 cycles or 3-4 cycles of ddMVAC for neoadjuvant muscle invasive bladder cancer treatment?  

For clinically node negative MIBC: I give 4 cycles of neoadjuvant chemotherapy either (preferably) dose dense MVAC with G-CSF or Gemzar/Cisplatin. For cN+ MIBC: I tend to restage after 3 cycles and consider up to 6 cycles for patients who can tolerate induction chemo and do not have interim progress...